This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Luisi, P.; Alvarez-Ponce, D.; Pybus, M.; Fares, M. A.; Bertranpetit, J.; Laayouni, H. 2015. Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome. Genome Biology and Evolution 7(4): 1141-1154.
Gineau, L. Luisi, P.; Castelli, E. C.;[4 authors]; Laayouni, H.; Moreau, P.; Donadi, E. A.; Garcia, A.; Sabbagh, A. 2015. Balancing immunity and tolerance: genetic footprint of natural selection in the transcriptional regulatory region of HLA-G. Genes& Immunity 16(1): 57-70.
Dobon, B.; Hassan, H.Y.; Laayouni, H.; Luisi, P.; Ricaño-Ponce, I.; Zhernakova, A.; Wijmenga, C.; Tahir, H.; Comas, D.; Netea, M.G.; Bertranpetit, J. 2015. The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape. Scientific Reports. 5.
Yamamoto, F.; Cid, E.; Yamamoto, M.; Saitou, N.; Bertranpetit, J.; and Blancher, A. 2014. An integrative evolution theory of histo-blood group ABO and related genes. Scientific Reports 4:6601.