The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.
Lab website: González Lab
Investigadora principal
Miembros del grupo
Proyectos en curso
Publicaciones
Lerat E.; Goubert C.; Guirao-Rico S.; Merenciano M.; Dufour A.-B.; Vieira C.; González J. 2019. Population-specific dynamics and selection patterns of transposable element insertions in European natural populations. Molecular Ecology. doi: 10.1111/mec.14963
Guirao-Rico S.; González J. 2019. Evolutionary insights from large scale resequencing datasets in Drosophila melanogaster. Current Opinion in Insect Science. 31:70-76 doi: 10.1016/j.cois.2018.11.002
Guio, Lain; González, Josefa 2019. New Insights on the Evolution of Genome Content: Population Dynamics of Transposable Elements in Flies and Humans. Methods in Molecular Biology. 505-530 doi: doi:10.1007/978-1-4939-9074-0_16
Fablet M.; Jacquet A.; Rebollo R.; Haudry A.; Rey C.; Salces-Ortiz J.; Bajad P.; Burlet N.; Jantsch M.F.; Guerreiro M.P.G.; Vieira C. 2019. Dynamic interactions between the genome and an endogenous retrovirus: Tirant in Drosophila simulans wild-type strains. G3: Genes, Genomes, Genetics. 9 (3):855-865 doi: 10.1534/g3.118.200789
Emmanuelle Lerat Clément Goubert, Sara Guirao-Rico Miriam Merenciano Anne-Béatrice Dufour Cristina Vieira ; González.; Josefa 2019. Population specific dynamics and selection patterns of transposable element insertions in European natural populations . Molecular Ecology. () doi: doi:10.1111/mec.14963