The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.

Lab website: González Lab

Investigadora principal Investigadora principal

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Publicaciones Publicaciones

Bogaerts-Márquez M, Barrón MG, Fiston-Lavier AS, Vendrell-Mir P, Castanera R, Casacuberta JM, González J 2019. T-lex3: an accurate tool to genotype and estimate population frequencies of transposable elements using the latest short-read whole genome sequencing data. Bioinformatics.  doi:org/10.1093/bioinformatics/btz727


Barrón M. G.; Paupy C.; Rahola N.; Akone-Ella O.; Ngangue M. F.; Wilson-Bahun T. A.; Pombi M.; Kengne P.; Costantini C.; Simard F.; González J.; Diego Ayala D.  2019. A new species in the major malaria vector complex sheds light on reticulated species evolution. Scientific Reports . 9/14753 doi: DOI: 10.1038/s41598-019-49065-5


Ullastres A.; Merenciano M. ; Gonzalez J.; 2019. Natural transposable element insertions drive expression changes in genes underlying Drosophila immune response. biorxiv. doi.org/10.1101/655225


Agostini R.B.; Postigo A.; Rius S.P.; Rech G.E.; Campos-Bermudez V.A.; Vargas W.A. 2019. Long-lasting primed state in maize plants: Salicylic acid and steroid signaling pathways as key players in the early activation of immune responses in silks. Molecular Plant-Microbe Interactions. 32 (1):90-106 doi: 10.1094/MPMI-07-18-0208-R


Mateo L.; Rech G.E.; González J. 2018. Genome-wide patterns of local adaptation in Western European Drosophila melanogaster natural populations. Scientific Reports. 8 (1):16143 doi: 10.1038/s41598-018-34267-0


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