The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.

Lab website: González Lab

Investigadora principal Investigadora principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Villanueva-Cañas, J.L.; Ruiz-Orera, J.; Agea, M.I.; Gallo, M.; Andreu, D.; Albà, M.M. 2017. New genes and functional innovation in mammals. Genome Biology and Evolution. 9 (7):1886-1900

Le Manh H.; Guio L.; Merenciano M.; Rovira Q.; Barrón M.G.; González J. 2017. Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster. Scientific Reports. 7:artículo 42663

Horváth, V.; Merenciano, M.; González, J. 2017. Revisiting the Relationship between Transposable Elements and the Eukaryotic Stress Response. Trends in Genetics. 33 (11):832-841

Merenciano, M.; Ullastres, A.; de Cara, M.A.; Barrón, M.G.; González, J. 2016. Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila. PLOS Genetics 12(8):e1006249

Bergland, A.O.; Tobler, R.; González, J.; Schmidt, P.; Petrov, D. 2016. Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogasterMolecular Ecology doi: 10.1111/mec.13455

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