The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.
Lab website: González Lab
Villanueva-Cañas, J.L.; Ruiz-Orera, J.; Agea, M.I.; Gallo, M.; Andreu, D.; Albà, M.M. 2017. New genes and functional innovation in mammals. Genome Biology and Evolution. 9 (7):1886-1900
Le Manh H.; Guio L.; Merenciano M.; Rovira Q.; Barrón M.G.; González J. 2017. Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster. Scientific Reports. 7:artículo 42663
Horváth, V.; Merenciano, M.; González, J. 2017. Revisiting the Relationship between Transposable Elements and the Eukaryotic Stress Response. Trends in Genetics. 33 (11):832-841