The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.
Lab website: González Lab
Salces-Ortiz J.; Vargas-Chavez C.; Guio L.; Rech G.E.; González J. 2020. Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster.. The Royal Society. 375(1795) doi: 10.1098/rstb.2019.0341
Ruiz-Arenas C.; Cáceres A.; López M.; Pelegrí-Sisó D.; González J. and González J.R. 2020. Identifying chromosomal subpopulations based on their recombination histories advances the study of the genetic basis of phenotypic traits. Genome Research. 30(12):1802-1814. doi: 10.1101/gr.258301.119.
Kapun M.; Barron M.; Staubach F.; ...[ 39 authors ]...Betancourt A.; Flatt T.; González J. 2020. Genomic analysis of European Drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses. molecular biology and evolution. doi.org/10.1093/molbev/msaa120
González J.R.; Ruiz-Arenas C.; Cáceres A.; Morán I.; López-Sánchez M.; Alonso L.; Tolosana I.; Guindo-Martínez M.; Mercader J.M.; Esko T.; Torrents D.; González J. and Pérez-Jurado L.A. 2020. Polymorphic Inversions Underlie the Shared Genetic Susceptibility of Obesity-Related Diseases. Am J Hum Genet. 106(6):846-858. doi: 10.1016/j.ajhg.2020.04.017.
Villanueva-Cañas J.L.; Horvath Aguilera;L. V; González, J 2019. Diverse families of transposable elements affect the transcriptional regulation of stress-response genes in Drosophila melanogaster. Nucleic Acids Research. doi:10.1093/nar/gkz490