Genómica evolutiva y funcional
The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.
Lab website: González Lab
Zhu Y, Bergland AO, González J, Petrov DA. 2012. Empirical validation of pooled whole genome population re-sequencing in Drosophila melanogaster. PLoS ONE, 7(7):1-7. DOI:10.1371/journal.pone.0041901
González J, Petrov DA. 2012. Evolution of genome content: population dynamics of transposable elements in flies and humans. Methods in Molecular Biology 855: 361-383.
Calvete O, González J, Betrán E, Ruiz A. 2012. Segmental duplication, microinversion, and gene loss associated with a complex inversion breakpoint region in drosophila. Molecular Biology and Evolution, 29(7):1875-1889. DOI:10.1093/molbev/mss067
Petrov DA, Fiston-Lavier AS, Lipatov M, Lenkov K, González J. 2011. Population genomics of transposable elements in drosophila melanogaster. Molecular Biology and Evolution, 28(5):1633-1644. DOI:10.1093/molbev/msq337
Fiston-Lavier AS, Carrigan M, Petrov DA, González J. 2011. T-lex: A program for fast and accurate assessment of transposable element presence using next-generation sequencing data. Nucleic Acids Research, 39(6):1-10. DOI:10.1093/nar/gkq129