The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.
Lab website: González Lab
Ullastres, A.; Petit, N.; González, J. 2015. Exploring the Phenotypic Space and the Evolutionary History of a Natural Mutation in Drosophila melanogaster. Molecular Biology and Evolution 32(7): 1800-1814.
Guio, L.; Gonzalez, J. 2015. The Dominance Effect of the Adaptive Transposable Element Insertion Bari-Jheh Depends on the Genetic Background. Genome Biology and Evolution 7(5): 1260-1266.
Gonzalez, J.; Martínez, J.; Makalowski, W. 2015. Lack of population differentiation patterns of previously identified putatively adaptive transposable element insertions at microgeographic scales. Biology Direct 10(1): 50.
Fiston-Lavier, A. S.; Barrón, M. G.; Petrov, D. A.; González, J. 2015. T-lex2: genotyping, frequency estimation and re-annotation of transposable elements using single or pooled next-generation sequencing data. Nucleic Acids Research 43(4): e22.