Principal Investigator: David Martín Principal Investigator: David Martín

 

Research lines Research lines

My group studies the hormonal control of insect embryogenesis, post-embryonic growth, molting and metamorphosis, particularly the roles of ecdysteroids and juvenile hormone. We are also interested in the hormonal basis of the evolution of metamorphosis.

In insects, the steroid hormone 20-hydroxyecdysone (20E) triggers major developmental transitions. The regulatory activity of this hormone is mediated by a genetic cascade of transcription factors that belong to the Nuclear Hormone Receptor superfamily (NRs). Whereas great deal of research has been devoted to uncover the molecular mechanisms regulating 20E-triggered cascade in holometabolous insects (Drosophila melanogaster), little understanding has been achieved regarding how these mechanisms operate in more primitive direct-developing hemimetabolous insects. To solve this, our research group is working to characterize the mechanisms of 20E action in the hemimetabolous insect, Blattella germanica. During the last years, we have cloned and characterized the entire repertoire of NRs that form the 20E-triggered genetic cascade in B. germanica and we have characterized their functional properties during embryonic, ninfal and adult development by using RNAi in vivo and parental RNAi procedures.

Furthermore, we are also working with another important hormone in insect development, that is Juvenile hormone (JH), which coordinates multiple developmental and physiological processes ranging from molting to reproduction and aging. Although discovered over 7 decades ago, the mechanism of JH action remains mostly unknown. Despite long-standing efforts and interest, the search for a JH receptor has not been successful. The overall goal of research in the lab is to uncover the molecular mechanism underlying JH action.

 

Lab website: Martín Lab

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Publications since 2011 Publications since 2011

Borras-Castells, F.; Nieva, C.; Maestro, J.L.; Maestro, O.; Belles, X.; Martín, D. 2017. Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1. Sci Rep 7:40234.

Ureña; E.; Chafino, S.; Manjón, C.; Franch-Marro, X.; and Martín, D. 2016. The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Krüppel-Homolog 1 and Broad-ComplexPLoS Genetics 12(5):e1006020

Ureña, E.; Pirone, L.; Chafino, S.; [5 authors]; Blanco, F. J.; Barrio, R.; Martín, D. 2016. Evolution of SUMO function and chain formation in insects. Molecular Biology and Evolution 33(2):568-84


Mansilla, A.; Martín, F.A.; Martín, D.; and Ferrús, A. 2016. Ligand-independent requirements of steroid receptors EcR and USP for cell survival. Cell Death & Differentiation 23: 405-416.


Herboso, L.; Oliveira, M. M.; Talamillo, A.; Pérez, C.; González, M.; Martín, D.; Sutherland, J. D.; Shingleton, A. W.; Mirth, C. K.; Barrio, R. 2015. Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster. Scientific Reports 5: 12383.


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Ongoing projects Ongoing projects

In the media In the media

On the publication of the article "The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Kr-h1 and Broad-Complex", with the participation of Xavier Franch-Marro and David Martín: