The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.

Lab website: González Lab

Investigadora principal Investigadora principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Guio L .; Vieira C .; González J. 2018. Stress affects the epigenéticos marks added by natural transposable elemento inserción in Drosophila melanogaster . Scientific Reports . 8 (1): 12197 doi: 10.1038 / s41598-018-30491-w

Calvete, O.; González, J.; Betran, E.; Ruiz, A.  2012. Segmental duplication, microinversion and gene loss associated with a complex inversion breakpoint region in Drosophila. Molecular Biology and Evolution 29 (7): 1875-1889.

González, J.; Petrov, D.A. 2012. Evolution of genome content: population dynamics of transposable elements in flies and humans. Methods in Molecular Biology 855: 361-383.

Fiston-Lavier, A.-S. C.; M.;Petrov, D. A.;González, J. 2011. T-lex: a program for fast and accurate assessment of transposable element presence using next-generation sequencing data. Nucleic Acids Research 39(6): e36-e36.

Zhu, Y.; Bergland, A.O.; González, J.; Petrov, D.A.  2012. Empirical validation of pooled genome population re-sequencing in Drosophila melanogaster. PLOS ONE 7 (7): e41901.

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