This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Dobon B.; Rossell C.; Walsh S.; Bertranpetit J. 2019. Is there adaptation in the human genome for taste perception and phase i biotransformation?. BMC Evolutionary Biology. 19(1):39 doi: 10.1186/s12862-019-1366-7
Dobon B.; Montanucci L.; Peretó J.; Bertranpetit J. and Laayouni H. 2019. Gene connectivity and enzyme evolution in the human metabolic network. Biology Direct. 17 doi:org/10.1186/s13062-019-0248-7
Nye J.; Laayouni H.; Kuhlwilm M.; Mondal M.; Marques-Bonet T.; Bertranpetit J. 2018. Selection in the Introgressed Regions of the Chimpanzee Genome. Genome biology and evolution. 10(4):1132-1138 doi: 10.1093/gbe/evy077
Montanucci L.; Laayouni L.; Dobon B.; Keys K.; Bertranpetit J.;Pereto J. 2018. Influence of pathway topology and functional class on the molecular evolution of human metabolic genes. Plos One. doi: 10.1371/journal.pone.0208782
Mondal M., Casals F., Majumder P.P., Bertranpetit J. 2018. Reply to ‘No evidence for unknown archaic ancestry in South Asia’. Nature Genetics. 50(12):1637-1639 doi: 10.1038/s41588-018-0280-z