This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.

Other websites: Bertranpetit Lab


Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Julià, A.; González, I.; Fernández-Nebro, A.; [17 authors]; Bertranpetit, J.; Absher, D.; Bridges, SL Jr.; Myers, RM.; Tornero, J. and Marsal, S. 2016. A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis. Rheumatology (Oxford) 55(6):1106-11.

Julià A.; Blanco F.; Fernández-Gutierrez.; B.; [17 authors]; Bertranpetit J.; Absher, D.; Myers R.M.; Tornero, J. and Marsal, S. 2016. Genome-Wide Association Study Identifies IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis. Arthritis Rheumatol 68(6):1384-91.

Fernández-Sampedro, M.A.; Invergo, B.M.; Ramon, E.; Bertranpetit, J.; and Garriga, P. (2016). Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolutionScientific Reports 6:21570. doi: 10.1038/srep21570.

Calafell, F.; Anglada, R.; Bonet, N.; González-Ruiz, M.; Prats-Muñoz, G.; Rasal, R.; Lalueza-Fox, C.; Bertranpetit, J.; Malgosa, A.; and Casals, F. (2016). An assessment of a massively parallel sequencing approach for the identification of individuals from mass graves of the Spanish Civil War (1936-1939)Electrophoresis [Epub ahead of print]

Cagan, A.; Theunert, C.; Laayouni, H.; Santpere, G.; Pybus, M.; Casals, F.; Prüfer, K.; Navarro, A.; Marques-Bonet, T.; Bertranpetit, J.; and Andres, A.M. (2016). Natural Selection in the Great Apes. Molecular Biology and Evolution 33 (12): 3268-3283.