This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Pybus, M., Dall'Olio, G.M.; Luisi, P.; Uzkudun, M.; Carreño-Torres, A.; Pavlidis, P.; Laayouni, H.; Bertranpetit, J.; and Engelken, J. 2014. 1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans. Nucleic Acids Research 42 (D1):D903-D909.
Laayouni, H.; Oosting, M.; Luisi, P.; Ioana, M.; Alonso, S.; Ricaño-Ponce, I.; Trynka, G.; Zhernakova, A.; Plantinga, T.S.; Cheng, S.; van der Meer, J.W.M.; Popp, R.; Sood, A.; Thelma, B.K.; Wijmenga, C.; Joosten, L.A.B.; Bertranpetit, J.; Netea, M.G. 2014. Convergent evolution in European and Rroma populations reveals pressure exerted by plague on Toll-like receptors. Proceedings of the National Academy of Sciences 111 (7):2668-2673.
Juyal, G.; Mondal, M.; Luisi, P.; Laayouni, H.; Sood, A.; Midha, V.; Heutink, P.; Bertranpetit, J.; Thelma, B.K.; and Casals, F. 2014. Population and genomic lessons from genetic analysis of two Indian populations. Human Genetics. 133 (10):1273-1287
Invergo, B.M.; Dell'Orco, D.; Montanucci, L.; Koch, K.-W.; and Bertranpetit, J. 2014. A comprehensive model of the phototransduction cascade in mouse rod cells. Molecular BioSystems 10 (6):1481-1489
Gineau, L.; Pierre, L.; Castelli, E.C.; Milet, J.; Courtin, D.; Cagnin, N.; Patillon, B.; Laayouni, H.; Moreau, P.; Donadi, E.A.; Garcia, A.; and Sabbagh, A. 2014. Balancing immunity and tolerance: genetic footprint of natural selection in the transcriptional regulatory region of HLA-G. Genes and Immunity 16, 57-70