This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.

Other websites: Bertranpetit Lab

 

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Cagliani R, Guerini FR, Rubio-Acero R, Baglio F, Forni D, Agliardi C, Griffanti L, Fumagalli M, Pozzoli U, Riva S, Calabrese E, Sikora M, Casals F, Comi GP, Bresolin N, Cáceres M, Clerici M, Sironi M. 2013. Long-Standing Balancing Selection in the THBS4 Gene: Influence on Sex-Specific Brain Expression and Gray Matter Volumes in Alzheimer Disease. Human Mutation, 34(5):743-753. DOI:10.1002/humu.22301


Brotherton P, Haak W, Templeton J, Brandt G, Soubrier J, Jane Adler C, Richards SM, Der Sarkissian C, Ganslmeier R, Friederich S, Dresely V, van Oven M, Kenyon R, Van der Hoek MB, Korlach J, Luong K, Ho SYW, Quintana-Murci L, Behar DM, Meller H, Alt KW, Cooper A; Genographic Consortium. 2013. Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nature Communications, 4. DOI:10.1038/ncomms2656


Botigué LR, Henn BM, Gravel S, Maples BK, Gignoux CR, Corona E, Atzmon G, Burns E, Ostrer H, Flores C, Bertranpetit J, Comas D, Bustamante CD. 2013. Gene flow from North Africa contributes to differential human genetic diversity in southern europe. Proceedings of the National Academy of Sciences of the United States of America, 110(29):11791-11796. DOI:10.1073/pnas.1306223110


Schurr, T.G.; Dulik, M.C.; Owings, A.C.; [3 authors]; Ramos, J.; Moss, M.B.; Natkong, F.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Clan, language, and migration history has shaped genetic diversity in Haidaand Tlingit populations from Southeast Alaska. American Journal of Physical Anthropology 148 (3): 422-435. PMID:22549307.

Sánchez-Quinto, F.; Schroeder, H.; Ramírez, O.; [6 authors]; Bertranpetit, J.; Orlando, L.; Gilbert, M.T.P.; Lalueza-Fox, C.  2012. Genomic affinities of two 7,000-year-old Iberian hunter-gatherers. Current Biology 22: 1494-1499. PMID: 22748318.

Meló, M.; Javed, A.; Pybus, M.; Zalloua, P.; Haber, M.; Comas, D.; [8 authors]; Calafell, F.; Bertranpetit, J.; The Genographic Consortium.  2012. Recombination gives a new insight in the effective population size and the history of the Old World human populations. Molecular Biology and Evolution 29 (1): 25-30.

Martínez-Cruz, B.; Harmant, C.; Platt, D.E.; [6 authors]; Oyharabal, B.; Quintana-Murci, L.; Comas, D. The Genographic Consortium [including J. Bertranpetit].  2012. Evidence of pre-Roman tribal genetic structure in Basques from uniparentally inherited markers. Molecular Biology and Evolution 29 (9): 2211-2222.

Martínez-Cruz, B.; Ioana, M.; Calafell, F.; [7 authors]; Plantiga, T.; van der Meer, J.W.M.; Comas, D.; Netea, M. The Genographic Consortium [including J. Bertranpetit]. 2012. Y-chromosome analysis in individuals bearing the Basarab name of the first dynasty of Wallachian kings. PLOS ONE 7 (7): e41803.

Lu, Y.; Wang, C.; Qin, Z.; Wen, B.; Farina, S.E.; Jin, L.; Li, H.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Mitochondrial origin of the matrilocal Mosuo people in China. Mitochondrial DNA 23 (1): 13-19. PMID: 22295860.

Luisi, P.; Álvarez-Ponce, D.; Dall’Olio, G.M.; Sikora, M.; Bertranpetit, J.; Laayouni, H.  2012. Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations. Molecular Biology and Evolution 29 (5): 1379-1392. PMID: 22135191.

Kang, L.; Lu, Y.; Wang, C.; Hu, K.; Chen, F.; Liu, K.; Li, S.; Jin, L.; Li, H.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012.Y-chromosome O3 haplogroup diversity in Sino-Tibetan populations reveals two migration routes into the easternHimalayas. Annals of Human Genetics 76 (1): 92-99. PMID: 22111786.

Javed, A.; Mel, M.; Pybus, M.; Zalloua, P.; Haber, M.; Comas, D.; [7 authors]; Bertranpetit, J.; Calafell, F.; Parida, L. The Genographic Consortium.  2012.Recombination networks as genetic markers: a human variation study of the Old World. Human Genetics 131 (4): 601-613.

Henn, B.M.; Botigu, L.R.; Gravel, S.; [6 authors];Bertranpetit, J.; Bustamante, C.D.; Comas, D.  2012. Genomic Ancestry of North Africans Supports Back-to-Africa Migrations. PLoS Genetics 8 (1): e1002397.

Dulik, M.C.; Owings, A.C.; Gaieski, J.B.; [8 authors]; Gibson, N.; Andrews, T.D.; Schurr, T.G.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Y-chromosomeanalysis reveals genetic divergence and new founding native lineages in Athapaskanand Eskimoan-speaking populations. Proceedings of the National Academy of Sciences USA 109 (22): 8471-8476. PMID: 22586127.

Dall’Olio, G.M.; Laayouni, H.; Luisi, P.; Sikora, M.; Montanucci, L.; Bertranpetit, J.  2012. Distribution of events of positive selection and population differentiation in a metabolic pathway: the case of asparagine N-glycosylation. BMC Evolutionary Biology 12 (1): 98. PMID: 22731960.

Casals, F.; Bertranpetit, J.  2012. Human Genetic Variation, Shared and Private. Science 337 (6090): 39-40.

Behar, D.M.; Harmant, C.; Manry, J.; [5 authors]; Bauduer, F.; Comas, D.; Quintana‑Murci, L. The Genographic Consortium [including J. Bertranpetit].  2012. The Basque Paradigm: Genetic Evidence of a Maternal Continuity in the Franco‑Cantabrian Region since Pre‑Neolithic Times. American Journal of Human Genetics 90: 486‑493.

ArunKumar, G.; Soria Hernández, D.F.; Kavitha, V.J.; [12 authors]; Smith, C.T.; Platt, D.E.; Pitchappan, R. The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Population Differentiation of Southern Indian Male Lineages Correlates with Agricultural Expansions Predating the Caste System. PLOS ONE 7 (11).

Sikora, M.; Laayouni, H.; Menendez, C.; [3 authors]; Mihai G. Netea; Ferran Casals; Jaume Bertranpetit  2011. A Targeted Association Study of Immunity Genes and Networks Suggests Novel Associations with Placental Malaria Infection. (2011). PLoS ONE 6(9): e24996. doi:10.1371/journal.pone.0024996

Sikora, M.; Laayouni, H.; Calafell, F.; Comas, D.; Bertranpetit, J. 2011. A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations. European Journal of Human Genetics 19: 84-88.

Parnell, L.D.; Pierre Lindenbaum; Khader Shameer; Giovanni Marco Dall’Olio; [4 authors]; Mary E. Mangan; Christopher A. Miller; Istvan Albert 2011. BioStar: An Online Question & Answer Resource for the Bioinformatics CommunityPLoS Comput Biol 7(10): e1002216. doi:10.1371/journal.pcbi.1002216

Montanucci, L.; Laayouni, H.; Dall'Olio, G. M.; Bertranpetit, J. 2011. Molecular evolution and network-level analysis of the N-glycosylation metabolic pathway across primates. Molecular Biology and Evolution 28: 813-823.

Laayouni H.; Montanucci L.; Sikora M.; [6 authors]; Bosch E.; Comas D.; Navarro A.; Calafell F.; Casals F.; Bertranpetit J. 2011. Similarity in recombination rate estimates highly correlates with genetic differentiation in humansPLoS ONE 6(3): e17913. doi:10.1371/journal.pone.0017913.

Javed A.; Pybus M.; Melé M.; Utro F.; Bertranpetit J.; Calafell F.; Parida L. 2011. IRiS*: Construction of ARG networks at genomic scales.  BioinformaticsAhead of print; PMID: 21765095.

Haber, M.; Platt, D. E.; Badro, D. A.; [14 authors]; Bertranpetit, J.; Clarke, A. C.; Comas, D.; [28 authors];Santhakumari, A. V.; Vieira, P. P.; Ziegle, J. S. 2011. Influences of history, geography, and religion on genetic structure: the Maronites in LebanonEuropean Journal of Human Genetics 19: 334-340.

Gaieski JB.; Owings AC.; Vilar MG.; Dulik MC.; Gaieski DF.; Gittelman RM.; Lindo J.; Gau L.; Schurr TG.; Genographic Consortium [Included Bertranpetit, J. and Comas, D.] 2011. Genetic ancestry and indigenous heritage in a Native American descendant community in Bermuda. Am J Phys Anthropol. 146(3):392-405.

Dall'Olio, G.M.; Marino, J.; Schubert, M.; [7 authors]; Jensen, L.J.; Bertranpetit, J.; Laayouni, H. 2011. Ten Simple Rules for Getting Help from Online Scientific CommunitiesPLoS Comput Biol 7(9): e1002202. doi:10.1371/journal.pcbi.1002202

Dall'olio, G. M.; Jassal, B.; Montanucci, L.; Gagneux, P.; Bertranpetit, J.; Laayouni, H. 2011. The annotation of the Asparagine N-linked Glycosylation pathway in the Reactome Database. Glycobiology 21(11): 1395-1400.

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