The object of study of the research group are the mechanisms that regulate the metamorphosis of insects , and how these mechanisms have evolved from ancestral species, with a gradual metamorphosis (like in cockroaches or locusts), to the most modified species, with a discontinuous metamorphosis (like in butterflies or flies). Therefore, the questions that the research group on the Evolution of insect metamorphosis seek to answer are: How did metamorphosis develop in insects? What endocrine and molecular mechanisms led to the evolutionary transition from gradual to discontinuous metamorphosis?

Lab website: Bellés Lab

 

Investigador principal Investigador principal

Membres del grup Membres del grup

Projectes en curs Projectes en curs

Publicacions Publicacions

Clark-Hachtel C, Fernandez-Nicolas A, Belles X, Tomoyasu Y. 2021. Tergal and pleural wing-related tissues in the German cockroach and their implication to the evolutionary origin of insect wingsEvolution & development, 23(2): 100–116. DOI: 10.1111/ede.12372.


Ventós-Alfonso A, Ylla G, Montañes JC, Belles X. 2020. DNMT1 Promotes Genome Methylation and Early Embryo Development in Cockroaches. iScience, 23(12). DOI:10.1016/j.isci.2020.101778


Kamsoi O, Belles X. 2020. E93-depleted adult insects preserve the prothoracic gland and molt again. Development, 147(22). DOI: 10.1242/dev.190066.


Wexler J.; Delaney E.; Belles X.; Schal C.; Wada-Katsumata A.; Amicucci M.; Kopp A. 2019. Hemimetabolous insects elucidate the origin of sexual development via
alternative splicing
. E Life. doi.org/10.7554/eLife.47490
 


Ventos A.; Ylla G. and Belles X. 2019. Zelda and the maternal-to-zygotic transition in cockroaches. The Febs Journal.  doi: 10.1111/febs.14856


Kamsoi O.; Belles X. 2019. Myoglianin triggers the pre-metamorphosis stage in hemimetabolan insects.. the fased journal. doi: 10.1096/fj.201801511R


Belles X 2019. Krüppel homolog 1 and E93: The doorkeeper and the key to insect metamorphosis. Wiley Online Library. doi:10.1002/arch.21609

 


Belles X 2019. The innovation of the final moult and the origin of insect metamorphosis. Royal Society. Doi: org/10.1098/rstb.2018.0415
 


Ylla, G.; Piulachs, M.D.; Belles, X. 2018. Comparative Transcriptomics in Two Extreme Neopterans Reveals General Trends in the Evolution of Modern Insects. iScience:164-179 doi: 10.1016/j.isci.2018.05.017


Ylla, G; Piulachs, M.D; Belles, X.  2018. Clues about the evolution of insect metamorphosis revealed by comparative transcriptomics of hemimetabolan and holometabolan species. iScience (Cell Press).  4:164–179  doi: 10.1016/j.isci.2018.05.017.


Rubio, M.; Maestro, J.L., Piulachs, M.D.; Belles, X. (2018) Conserved association of Argonaute 1 and 2 proteins with miRNA and siRNA pathways throughout insect evolution, from cockroaches to flies. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1861(6):554-560 doi: 10.1016/j.bbagrm.2018.04.001


Llonga N.; Ylla G.; Bau J.; Belles X.; Piulachs M.-D. 2018. Diversity of piRNA expression patterns during the ontogeny of the German cockroach. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 330(5):288-295 doi: 10.1002/jez.b.22815


Jongepier E.; Kemena C.; Lopez-Ezquerra A.; Belles X.; Bornberg-Bauer E.; Korb J. 2018. Remodeling of the juvenile hormone pathway through caste-biased gene expression and positive selection along a gradient of termite eusociality. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 330(5):296-304 doi: 10.1002/jez.b.22805


Huang J.-H.; Liu Y.; Lin Y.-H.; Belles X.; Lee H.-J. 2018. Practical use of RNA interference: Oral delivery of double-stranded RNA in liposome carriers for cockroaches. Journal of Visualized Experiments. 2018(135): e57385 doi: 10.3791/57385


Harrison, M.C.; Jongepier, E.; Robertson, H.M.; …[23 authors]…; Piulachs, M.D: …[6 authors]… ; Ylla, G.; …[3 authors]…; Richards, S.; Belles, X.; Korb, J.; Bornberg-Bauer, E. 2018. Hemimetabolous genomes reveal molecular basis of termite eusociality. Nature Ecology and Evolution. 2(3):557-566 doi: 10.1038/s41559-017-0459-1


Harrison M.C.; Arning N.; Kremer L.P.M.; Ylla G.; Belles X.; Bornberg-Bauer E.; Huylmans A.K.; Jongepier E.; Piulachs M.-D.; Richards S.; Schal C. 2018. Expansions of key protein families in the German cockroach highlight the molecular basis of its remarkable success as a global indoor pest. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 330(5):254-264 doi: 10.1002/jez.b.22824


Bukejs A.; Belles X.; Alekseev V.I. 2018. A new species of Dignomus Wollaston (Coleoptera: Ptinidae) from Eocene Baltic amber. Zootaxa. 4486(2):195-200 doi: 10.11646/zootaxa.4486.2.9


Lin,Y.;Huang, J.; Liu, Y.; Belles, X.; Lee, H. 2017. Oral delivery of dsRNA lipoplexes to German cockroach protects dsRNA from degradation and induces RNAi response Pest Management Science. 73: 5, 960-966

Korb J.; Belles X. 2017. Juvenile hormone and hemimetabolan. Current Opinion in Insect Science. 22:109-116


Fernandez-Nicolas A.; Belles X. 2017. Juvenile hormone signaling in short germ-band hemimetabolan embryos. Development. 144(24):4637-4644


Borras-Castells, F.; Nieva, C.; Maestro, J.L.; Maestro, O.; Belles, X.; Martín, D. 2017. Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1. Sci Rep 7:40234.

Bellés, X. 2017. MicroRNAs and the Evolution of Insect Metamorphosis. Annual review of entomology 62:111-25

Ylla, G.; Fromm, B.; Piulachs, M.D.; and Belles, X. 2016. The microRNA toolkit of insects. Scientific Reports 6:37736. doi: 10.1038/srep37736

Santos, C.G.; Fernandez-Nicolas, A.; and Belles, X. 2016. Smads and insect hemimetabolan metamorphosisDevelopmental Biology 417(1):104-13

Fernández-Nicolás, A.; and Bellés, X. (2016). CREB-binding protein contributes to the regulation of endocrine and developmental pathways in insect hemimetabolan pre-metamorphosisBiochimica et Biophysica Acta 1860: 508–515

Elias-Neto, M.; and Belles, X. (2016). Tergal and pleural structures contribute to the formation of ectopic prothoracic wings in cockroachesRoyal Society Open Science 3: 160347

Ons, S.; Bellés, X.; Maestro, J. L. 2015. Orcokinins contribute to the regulation of vitellogenin transcription in the cockroach Blattella germanica. Journal of Insect Physiology 82: 129-133.


Lozano, J.; Montañez, R.; Belles, X. 2015. MiR-2 family regulates insect metamorphosis by controlling the juvenile hormone signaling pathway. Proceedings of the National Academy of Sciences 112(12): 3740-3745.


Jindra, M.; Bellés, X.; Shinoda, T. 2015. Molecular basis of juvenile hormone signalingCurrent Opinion in Insect Science 11: 39-46.


Dillon, M. B. C.; Sulchten, V.; Oseroff, C.; Paul, S.; Dullanty, L. M.; Frazier, A.; Belles, X.; Piulachs, M. D.; [4 authors]; Sidney, J.; Peters, B.; Sette, A. 2015. Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects. Clinical & Experimental Allergy 45(12): 1856-1867.


Belles, X.; Ylla, G. 2015. Towards understanding the molecular basis of cockroach tergal gland morphogenesis. A transcriptomic approach.  Insect Biochemistry and Molecular Biology 63(0): 104-112.


Belles, X.; Piulachs, M-D. 2015. Ecdysone signalling and ovarian development in insects: from stem cells to ovarian follicle formation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849(2): 181-186.


Patiño-Navarrete, R.; Piulachs, M.D.; Belles, X.; Moya, A.; Latorre, A.; and Peretó, J. 2014. The cockroach Blattella germanica obtains nitrogen from uric acid through a metabolic pathway shared with its bacterial endosymbiont. Biology Letters 10 (7)


Lozano, J.; Kayukawa, T.; Shinoda, T.; and Belles, X. 2014. A Role for Taiman in Insect Metamorphosis. PLoS Genetics 10(10): e1004769.


Herraiz, A.; Belles, X.; and Piulachs, M.D. 2014. Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9. Experimental Cell Research 320 (1):46-53.


Rubio, M.;  Belles, X. 2013. Subtle roles of microRNAs let-7, miR-100 and miR-125 on wing morphogenesis in hemimetabolan metamorphosis. Journal of Insect Physiology. 59 (11):1089-1094

Rubio, M.;  Montañez, R.; Perez, LidiaMilan, M.; Belles, X. 2013. Regulation of atrophin by both strands of the mir-8 precursor. Insect Biochemistry and Molecular Biology. 43 (11):1009-1014


Huang, J.-H.;  Lozano, J.; Belles, X. 2013. Broad-complex functions in postembryonic development of the cockroach Blattella germanica shed new light on the evolution of insect metamorphosis. Biochimica et Biophysica Acta (BBA) - General Subjects 1830(1): 2178-2187

Garbutt, J.S.;  Bellés, X.; Richards, E. H.; Reynolds, S. E. 2013. Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: Evidence from Manduca sexta and Blattella germanicaJournal of Insect Physiology. 59 (2):171-8.


Rubio, M.; de Horna, A.; Bellés, X.  2012. MicroRNAs in metamorphic and non-metamorphic transitions in hemimetabolan insect metamorphosis. BMC Genomics 13: 386. doi: 10.1186/1471-2164-13-386.

Mané-Padrós, D.; Borr.s-Castells, F.; Bellés, X.; Martín, D.  2012. Nuclear receptor HR4 plays an essential role in the ecdysteroid-triggered gene cascade in the development of the hemimetabolous insect Blattella germanica. Molecular and Cellular Endocrinology 348: 322-330.

Lozano, J.; Gómez-Orte, E.; Lee, H.J.; Bellés, X.  2012. Super-induction of Dicer-2 expression by alien double-stranded RNAs. An evolutionary ancient response to viral infection? Development, Genes and Evolution 222: 229-235.

Huang, J.H.; Bellés, X. Lee, H.J.  2012. Functional characterization of hypertrehalosemic hormone receptor in relation to hemolymph trehalose and to oxidative stress in the cockroach Blattella germanica. Frontiers in Experimental Endocrinology 2: 114. doi: 10.3389/fendo.2011.00114.

Boher, F.; Trefault, N.; Piulachs, M.D.; Bellés, X.; Godoy-Herrera, R.; Bozinovic, F.  2012. Biogeographic origin and thermal acclimation interact to determine survival and hsp90 expression in Drosophila species submitted to thermal stress. Comparative Biochemistry and Physiology, Part A 162: 391-396.

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