This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Walsh S.; Izquierdo-Serra M.; Acosta S.; Edo A.; Lloret M.; Moret R.; Bosch E.; Oliva B.; Bertranpetit J. and Fernández-Fernández J.M. 2020. Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population. Scientific Reports. 10(1):20999. doi: 10.1038/s41598-020-78081-z.
Walsh S.; Pagani L.; Xue Y.; Laayouni H.; Tyler-Smith C. and Bertranpetit J. 2020. Positive selection in admixed populations from Ethiopia. BMC Genet. 21(Suppl1):108 doi: 10.1186/s12863-020-00908-5.
García-Fernández C.; Font-Porterias N.; Kučinskas V.; Sukarova-Stefanovska E.; Pamjav H.; Makukh H.; Dobon B.; Bertranpetit J.; Netea M.G.; Calafell F. and Comas D. 2020. Sex-biased patterns shaped the genetic history of Roma. Sci Rep. 10(1):14464 doi: 10.1038/s41598-020-71066-y. Author Correction: Sci Rep. 10(1):18142 doi: 10.1038/s41598-020-75277-1.
Dobon B.; Ter Horst R.; Laayouni H.; Mondal M.; Bianco E.; Comas D.; Ioana M.; Bosch E.; Bertranpetit J. and Netea M.G. 2020. The shaping of immunological responses through natural selection after the Roma Diaspora. Sci Rep. 10(1):16134 doi: 10.1038/s41598-020-73182-1.
Bianco E.; Laval G.; Font-Porteries N.; …[ 9 authors ] … Bertranpetit J.; Calafell F.; Comas D. 2020. Recent common origin, reduced population size, and marked admixture have shaped European Roma genomes. Molecular Biology and Evolution. doi.org/10.1093/molbev/msaa156