This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Bianco E.; Laval G.; Font-Porteries N.; …[ 9 authors ] … Bertranpetit J.; Calafell F.; Comas D. 2020. Recent common origin, reduced population size, and marked admixture have shaped European Roma genomes. Molecular Biology and Evolution. doi.org/10.1093/molbev/msaa156
Mondal M.;Bertranpetit J.; Lao O. 2019. Approximate Bayesian computation with deep learning supports a third archaic introgression in Asia and Oceania. Nature comucications. 10(1):246 doi: 10.1038/s41467-018-08089-7.
Dobon B.; Rossell C.; Walsh S.; Bertranpetit J. 2019. Is there adaptation in the human genome for taste perception and phase i biotransformation?. BMC Evolutionary Biology. 19(1):39 doi: 10.1186/s12862-019-1366-7
Dobon B.; Montanucci L.; Peretó J.; Bertranpetit J. and Laayouni H. 2019. Gene connectivity and enzyme evolution in the human metabolic network. Biology Direct. 17 doi:org/10.1186/s13062-019-0248-7
Nye J.; Laayouni H.; Kuhlwilm M.; Mondal M.; Marques-Bonet T.; Bertranpetit J. 2018. Selection in the Introgressed Regions of the Chimpanzee Genome. Genome biology and evolution. 10(4):1132-1138 doi: 10.1093/gbe/evy077