This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Nye J.; Laayouni H.; Kuhlwilm M.; Mondal M.; Marques-Bonet T.; Bertranpetit J. 2018. Selection in the Introgressed Regions of the Chimpanzee Genome. Genome biology and evolution. 10(4):1132-1138 doi: 10.1093/gbe/evy077
Mattle-Greminger M.P.; Bilgin Sonay T.; Nater A.; ...[5 authors]...; Bertranpetit J.; Marques-Bonet T.; Van Schaik C.P.; Anisimova M.; Krützen M.. Genomes reveal marked differences in the adaptive evolution between orangutan species. Genome Biology. 19(1):193 doi: 10.1186/s13059-018-1562-6
Casillas, S.; Mulet, R.; Villegas-Mirón, P.; Hervas, S.; Sanz, E.; Velasco, D.; Bertranpetit, J.; Laayouni, H.; Barbadilla, A. (2018) PopHuman: The human population genomics browser. Nucleic Acids Research. 46(D1):D1003-D1010 doi: 10.1093/nar/gkx943
Nagle N.;Van Oven M.;Wilcox S.;[17 authors];Comas D.;Cooper A;[30 authors];Wells R.S.;Zalloua P.A.;Ziegle J.S. 2017. Aboriginal Australian mitochondrial genome variation - An increased understanding of population antiquity and diversity. Scientific Reports . 7:artículo 43041