This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.

Other websites: Bertranpetit Lab

 

Investigador principal Investigador principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Haber, M.;  Gauguier, D.;  Youhanna, S.;  [7 authros];  Bertranpetit, J.;  Tyler-Smith, C.;  Comas, D.;  Zalloua. P.A. 2013. Genome-Wide Diversity in the Levant Reveals Recent Structuring by Culture. PLoS Genetic. 9 (2):e1003316


Cagliani, R; Guierini F. R.; Rubio-Acero, R;[8 authors];Sikora, M; Casals, F; Comi, G. P; Bresolin, N; Cáceres, M; Clerici, M; Sironi, M. 2013. Long-Standing Balancing Selection in the THBS4 Gene: Influence on Sex-Specific Brain Expression and Gray Matter Volumes in Alzheimer Disease. Human Mutation. 34 (5):743-753


Brotherton, P.H; W.; Templeton, J.; Brandt, G.;[20 authors]; Bertranpetit, J.;   Comas, D.;  [3 authors];  Parida, L, : Vieira, P.P.;  Ziegle, J.S; for The Genographic Consortium. 2013. Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nat Commun. 4:1764


Botigue, L. R.; Henn, B. M.; Gravel, S.; [7 authors]; Bertranpetit, J.; Comas, D.; Bustamante, C. D. 2013. Gene flow from North Africa contributes to differential human genetic diversity in southern Europe. Proceedings of the National Academy of Sciences of the United States of America. 110 (29):11791-11796


Schurr, T.G.; Dulik, M.C.; Owings, A.C.; [3 authors]; Ramos, J.; Moss, M.B.; Natkong, F.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Clan, language, and migration history has shaped genetic diversity in Haidaand Tlingit populations from Southeast Alaska. American Journal of Physical Anthropology 148 (3): 422-435. PMID:22549307.