This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.

Other websites: Bertranpetit Lab

 

Investigador principal Investigador principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Meló, M.; Javed, A.; Pybus, M.; Zalloua, P.; Haber, M.; Comas, D.; [8 authors]; Calafell, F.; Bertranpetit, J.; The Genographic Consortium.  2012. Recombination gives a new insight in the effective population size and the history of the Old World human populations. Molecular Biology and Evolution 29 (1): 25-30.

Martínez-Cruz, B.; Harmant, C.; Platt, D.E.; [6 authors]; Oyharabal, B.; Quintana-Murci, L.; Comas, D. The Genographic Consortium [including J. Bertranpetit].  2012. Evidence of pre-Roman tribal genetic structure in Basques from uniparentally inherited markers. Molecular Biology and Evolution 29 (9): 2211-2222.

Martínez-Cruz, B.; Ioana, M.; Calafell, F.; [7 authors]; Plantiga, T.; van der Meer, J.W.M.; Comas, D.; Netea, M. The Genographic Consortium [including J. Bertranpetit]. 2012. Y-chromosome analysis in individuals bearing the Basarab name of the first dynasty of Wallachian kings. PLOS ONE 7 (7): e41803.

Lu, Y.; Wang, C.; Qin, Z.; Wen, B.; Farina, S.E.; Jin, L.; Li, H.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Mitochondrial origin of the matrilocal Mosuo people in China. Mitochondrial DNA 23 (1): 13-19. PMID: 22295860.

Luisi, P.; Álvarez-Ponce, D.; Dall’Olio, G.M.; Sikora, M.; Bertranpetit, J.; Laayouni, H.  2012. Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations. Molecular Biology and Evolution 29 (5): 1379-1392. PMID: 22135191.