This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.

Other websites: Bertranpetit Lab

 

Investigador principal Investigador principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Luisi, P.; Álvarez-Ponce, D.; Dall’Olio, G.M.; Sikora, M.; Bertranpetit, J.; Laayouni, H.  2012. Network-level and population genetics analysis of the insulin/TOR signal transduction pathway across human populations. Molecular Biology and Evolution 29 (5): 1379-1392. PMID: 22135191.

Kang, L.; Lu, Y.; Wang, C.; Hu, K.; Chen, F.; Liu, K.; Li, S.; Jin, L.; Li, H.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012.Y-chromosome O3 haplogroup diversity in Sino-Tibetan populations reveals two migration routes into the easternHimalayas. Annals of Human Genetics 76 (1): 92-99. PMID: 22111786.

Javed, A.; Mel, M.; Pybus, M.; Zalloua, P.; Haber, M.; Comas, D.; [7 authors]; Bertranpetit, J.; Calafell, F.; Parida, L. The Genographic Consortium.  2012.Recombination networks as genetic markers: a human variation study of the Old World. Human Genetics 131 (4): 601-613.

Henn, B.M.; Botigu, L.R.; Gravel, S.; [6 authors];Bertranpetit, J.; Bustamante, C.D.; Comas, D.  2012. Genomic Ancestry of North Africans Supports Back-to-Africa Migrations. PLoS Genetics 8 (1): e1002397.

Dulik, M.C.; Owings, A.C.; Gaieski, J.B.; [8 authors]; Gibson, N.; Andrews, T.D.; Schurr, T.G.; The Genographic Consortium [including D. Comas and J. Bertranpetit].  2012. Y-chromosomeanalysis reveals genetic divergence and new founding native lineages in Athapaskanand Eskimoan-speaking populations. Proceedings of the National Academy of Sciences USA 109 (22): 8471-8476. PMID: 22586127.