This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.

Other websites: Bertranpetit Lab

 

Investigador principal Investigador principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Sikora, M.; Laayouni, H.; Calafell, F.; Comas, D.; Bertranpetit, J. 2011. A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations. European Journal of Human Genetics 19: 84-88.

Parnell, L.D.; Pierre Lindenbaum; Khader Shameer; Giovanni Marco Dall’Olio; [4 authors]; Mary E. Mangan; Christopher A. Miller; Istvan Albert 2011. BioStar: An Online Question & Answer Resource for the Bioinformatics CommunityPLoS Comput Biol 7(10): e1002216. doi:10.1371/journal.pcbi.1002216

Montanucci, L.; Laayouni, H.; Dall'Olio, G. M.; Bertranpetit, J. 2011. Molecular evolution and network-level analysis of the N-glycosylation metabolic pathway across primates. Molecular Biology and Evolution 28: 813-823.

Laayouni H.; Montanucci L.; Sikora M.; [6 authors]; Bosch E.; Comas D.; Navarro A.; Calafell F.; Casals F.; Bertranpetit J. 2011. Similarity in recombination rate estimates highly correlates with genetic differentiation in humansPLoS ONE 6(3): e17913. doi:10.1371/journal.pone.0017913.

Javed A.; Pybus M.; Melé M.; Utro F.; Bertranpetit J.; Calafell F.; Parida L. 2011. IRiS*: Construction of ARG networks at genomic scales.  BioinformaticsAhead of print; PMID: 21765095.