This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Montanucci L.; Laayouni L.; Dobon B.; Keys K.; Bertranpetit J.;Pereto J. 2018. Influence of pathway topology and functional class on the molecular evolution of human metabolic genes. Plos One. doi: 10.1371/journal.pone.0208782
Mondal M., Casals F., Majumder P.P., Bertranpetit J. 2018. Reply to ‘No evidence for unknown archaic ancestry in South Asia’. Nature Genetics. 50(12):1637-1639 doi: 10.1038/s41588-018-0280-z
Mattle-Greminger M.P.; Bilgin Sonay T.; Nater A.; …[6 authors]…Marques-Bonet T.; Van Schaik C.P.; Anisimova M.; Krützen M2018. Genomes reveal marked differences in the adaptive evolution between orangutan species. Genome Biology. 19(1):193 doi: 10.1186/s13059-018-1562-6
Maja P. Mattle-Greminger.;Tugce Bilgin Sonay.; Alexander Nater.;…[ 2 authors]…;Jaume Bertranpetit.; Tomas Marques-Bonet.; Carel P. van Schaik.; Maria Anisimova.; Michael Krützen. 2018. Genomes reveal marked differences in the adaptive evolution between orangutan species. Genome Biology. 19-193 doi: 10.1186/s13059-018-1562-6
Casillas, S.; Mulet, R.; Villegas-Miron, P.; Hervas, S.; Sanz, E.; Velasco, D.; Bertranpetit, J.; Laayouni, H.; Barbadilla, A. (2018) PopHuman: The human population genomics browser. Nucleic Acids Research. 46(D1):D1003-D1010 doi: 10.1093/nar/gkx943