This lab’s main line of research at present focuses on the understanding of natural selection and adaptation in humans and primates through the comparative analysis of genomes. Its purpose is to understand complex adaptations through genome-wide analyses of the footprints that natural selection has left in genomes and attempt to place selection in a functional molecular framework of molecular pathways. The Evolutionary Systems Biology Lab is studying differential adaptation among human populations, including several African populations, Roma (as compared to Romanians and Indians) and in Chimpanzees. It has launched a project with the analysis of the haploid sequences of several individuals from all known groups of Southeast Asian pygmies.
Other websites: Bertranpetit Lab
Gineau, L.; Pierre, L.; Castelli, E.C.; Milet, J.; Courtin, D.; Cagnin, N.; Patillon, B.; Laayouni, H.; Moreau, P.; Donadi, E.A.; Garcia, A.; and Sabbagh, A. 2014. Balancing immunity and tolerance: genetic footprint of natural selection in the transcriptional regulatory region of HLA-G. Genes and Immunity 16, 57-70
Dall'Olio, G.M.; Bertranpetit, J.; Wagner, A.; and Laayouni, H. 2014. Human Genome Variation and the Concept of Genotype Networks. Plos One 9 (6):e99424
Colonna, V.; Ayub, Q.; Chen, Y.; Pagani, L.; Luisi, P.; Pybus, M.; Garrison, E.; Xue, Y.; and Tyler-Smith, C. 2014. Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences. Genome Biology. 15 (6):R88.
Colombo, M.; Laayouni H.; Invergo, B.M.; Bertranpetit, J.; and Montanucci, L. 2014. Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes.Evolution. Evolution. 68 (2):605-613
Clarke, A.C.; Prost,S.; Stanton, J.A.; White, W.T.; Kaplan, M.E.; Matisoo-Smith, E.A.; and Genographic Consortium. 2014. From cheek swabs to consensus sequences: an A to Z protocol for high-throughput DNA sequencing of complete human mitochondrial genomes. BMC Genomics 15(1): 68.