This lab carries out research into different aspects of human genetic diversity, such as the architecture of the genetic predisposition to complex disease and of human adaptation. To this end, sequencing data from different control/case settings or geographically diverse populations are often analysed, and methods for rare variant association and genome-wide detection of selection are subsequently applied. By using in silico predictions, molecular biology techniques and phenotypic data, the Evolutionary Population Genetics lab aims to elucidate the genetic variants and molecular phenotypes underlying the functional basis of different human adaptations.

Lab website: Bosch Lab

Investigadora principal Investigadora principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Flores-Bello A.; Mas-Ponte D.; Rosu M.E.; Bosch E.; Calafell F.; Comas D. 2018. Sequence diversity of the Rh blood group system in Basques. European Journal of Human Genetics. (): doi: 10.1038/s41431-018-0232-1


Spataro, N.; Rodríguez, J.A.; Navarro, A.; and Bosch, E. 2017. Properties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology. Hum Mol Genet.

Spataro N.; Roca-Umbert A.; Cervera-Carles L.; Vallès M.; Anglada R.; Pagonabarraga J.; Pascual-Sedano B.; Campolongo A.; Kulisevsky J.; Casals F.; Clarimón J.; Bosch E. 2017. Detection of genomic rearrangements from targeted resequencing data in Parkinson's disease patients. Movement Disorders. 32(1):165-169


Rodríguez, J.A.; Marigorta, U.M.; Hughes, D.A.; Spataro, N.; Bosch, E.; Navarro, A. 2017. Antagonistic pleiotropy and mutation accumulation influence human senescence and disease. Nature Ecology & Evolution 1:0055

Delgado, J.; Bielig, T.; Bonet, L.; Carnero-Montoro, E.; Puente, X.S.; Colomer, D.; Bosch, E.; Campo, E.; Lozano, F. 2017. Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimensBritish Journal of Haematology 177(1):147-150

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