This lab carries out research into different aspects of human genetic diversity, such as the architecture of the genetic predisposition to complex disease and of human adaptation. To this end, sequencing data from different control/case settings or geographically diverse populations are often analysed, and methods for rare variant association and genome-wide detection of selection are subsequently applied. By using in silico predictions, molecular biology techniques and phenotypic data, the Evolutionary Population Genetics lab aims to elucidate the genetic variants and molecular phenotypes underlying the functional basis of different human adaptations.

Lab website: Bosch Lab

Investigadora principal Investigadora principal

Miembros del grupo Miembros del grupo

Proyectos en curso Proyectos en curso

Publicaciones Publicaciones

Carnero-Montoro, E.; Bonet, L.; Engelken, J.; Bielig, T.; Martínez-Florensa, M.; Lozano, F.; Bosch, E.  2012. Evolutionary and functional evidence for positive selection at the human CD5 immune receptor gene. Molecular Biology and Evolution 29 (2): 811-823.

Gazave E, D. F.; Morcillo-Suarez C.; Petit-Marty N.; [5 authors]; Bosch E.; Baker C.; Marquès-Bonet T.; Eichler EE.; Navarro A. 2011. Copy number variation analysis in the great apes reveals species-specific patterns of structural variationGenome Research 21: 1626-1639.

Laayouni H.; Montanucci L.; Sikora M.; [6 authors]; Bosch E.; Comas D.; Navarro A.; Calafell F.; Casals F.; Bertranpetit J. 2011. Similarity in recombination rate estimates highly correlates with genetic differentiation in humansPLoS ONE 6(3): e17913. doi:10.1371/journal.pone.0017913.

Myles, S.; Lea, R. A.; Ohashi, J.; [3 authors]; Engelken, J.; [4 authors]; Inaoka, T.; Matsumura, Y.; Stoneking, M. 2011. Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans. BMC Medical Genetics 12: 10.

Delgado, J.; Bielig, T.; Bonet, L.; Carnero-Montoro, E.; Puente, X.S.; Colomer, D.; Bosch, E.; Campo, E.; Lozano, F. 2017. Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimensBritish Journal of Haematology 177(1):147-150

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