The study of the structure, function and organisation of ancestral genomes are the focal points of the Paleogenomics lab. More specifically, it looks at the different evolutionary problems that can be answered with ancient DNA data, such as those involving human evolution, population dynamics and diversity, as well as adaptive processes and past migrations. This lab works with ancient modern humans and with an extinct hominin species, Neanderthals. Regarding the latter, the research carried out to date has mainly been focused on genomic diversity among Neanderthals and the individualisation of a Neanderthal family group from El Sidrón, an archaeological site in the Asturias region of northern Spain. The Paleogenomics lab is also investigating the evolutionary dynamics and past migrations in European prehistory through the analysis of Mesolithic, Neolithic, Copper Age and Bronze Age human genomes.
Lab website: Paleogenomics Lab
Sikora, M.; Carpenter, M.L.; Moreno-Estrada, A.; Henn, B.M.; Underhill, P.A.; Sánchez-Quinto, F.; [17 authors]; Cucca, F.; and Bustamante, C.D. 2014. Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe. PLoS Genetics 10 (5):e1004353
Ramirez, O.; Burgos-Paz, W.; Casas, E.; Ballester, M.; Bianco, E.; Olalde, I.; Santpere, G.; Novella, V.; Gut, M.; Lalueza-Fox, C.; Sana, M.; and Perez-Enciso, M. 2014. Genome data from a sixteenth century pig illuminate modern breed relationships. Heredity 114, 175–184
Ramírez, O.; Quintanilla, R.; Varona, L.; Gallardo, D.; Díaz, I.; Pena, R.N.; and Amills, M. 2014. DECR1 and ME1 genotypes are associated with lipid composition traits in Duroc pigs. Journal of Animal Breeding and Genetics 131 (1):46-52
Ramirez, O.; Olalde, I.; Berglund, J.; Lorente-Galdos, B.; Hernandez-Rodriguez, J.; Quilez, J.; Webster, M.; Wayne, R.; Lalueza-Fox, C.; Vila, C.; and Marques-Bonet, T. 2014. Analysis of structural diversity in wolf-like canids reveals post-domestication variants. BMC Genomics 15 (1):465
Olalde, I.; Sánchez-Quinto, F.; Datta, D.;[12 authors]; Navarro, A.; Himmelbauer, H.; Marquès-Bonet, T.; Lalueza-Fox, C. 2014. Genomic analysis of the blood attributed to Louis XVI (1754-1793), king of France. Scientific Reports 4: 4666