The research carried out by this lab aims at understanding the mechanisms that regulate insect oogenesis. The model used is Blattella germanica, an insect with a panoistic ovary type, which is the most primitive ovary type among insects. This lab studies the expression of the genes involved in the main signalling pathways and its regulation by hormones and by the small non-coding RNA that modulates them. The comparison of these results with those already described in other, more modified insect species, suggests that some functions are preserved in evolution, although the regulation of these functions could have changed.
Lab website: Insect Reproduction Lab
Elshaer, N. P., M.-D. 2015. Crosstalk of EGFR signalling with Notch and Hippo pathways to regulate cell specification, migration and proliferation in cockroach panoistic ovaries. Biology of the Cell 107(8): 273-285.
Dillon, M. B. C.; Sulchten, V.; Oseroff, C.; Paul, S.; Dullanty, L. M.; Frazier, A.; Belles, X.; Piulachs, M. D.; [4 authors]; Sidney, J.; Peters, B.; Sette, A. 2015. Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects. Clinical & Experimental Allergy 45(12): 1856-1867.
Carot-Sans, G.; Muñoz, L.; Piulachs, M. D.; Guerrero, A.; Rosell, G. 2015. Identification and characterization of a fatty acyl reductase from a Spodoptera littoralis female gland involved in pheromone biosynthesis. Insect Molecular Biology 24(1): 82-92.
Belles, X.; Piulachs, M-D. 2015. Ecdysone signalling and ovarian development in insects: from stem cells to ovarian follicle formation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1849(2): 181-186.