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The goal of this lab is to understand the origin of animal multicellularity from a unicellular ancestor. To this end, the genomes of animals’ closest unicellular relatives are obtained in order to perform comparative and functional genomics. Moreover, the Multicellgenome lab is working on the development of genetic tools in two close unicellular relatives of animals with the purpose of establishing them as model organisms for addressing the origin of Metazoa. This will enable the elucidation of the ancestral function of the genes involved in multicellularity and offer insight into how they were co-opted.
Lab website: Multicellgenome Lab
Investigador principal
Miembros del grupo
Proyectos en curso
Publicaciones
O’Malley M.A.; Leger M.; Wideman J.G.; Ruiz-Trillo I. 2019. Concepts of the last eukaryotic common ancestor. Nature Ecology & Evolution. () doi: 10.1038/s41559-019-0796-3
Ocaña, E.; Najle, S.: Scazzocchio, C.; Ruiz, I. 2019. Reticulate evolution in eukaryotes: Origin and
evolution of the nitrate assimilation pathway. Plos Genetics. 15(2 doi: 10.1101/454272
Rafels-Ybern A.; Gabriel Torres A.; Camacho N.; Herencia-Ropero A.; Roura Frigolé H.;Wulff T.F.;Raboteg M.; Bordons A.; Grau-Bove X.; Ruiz-Trillo I.; Ribas de Pouplana LL. 2018. The expansion of Inosine at the wobble position of tRNAs, and its role in the evolution of proteomes. Molecular. (): doi: 10.1093/molbev/msy245
Waller R.F., Cleves P.A., Rubio-Brotons M., Woods A., Bender S.J., Edgcomb V., Gann E.R., Jones A.C., Teytelman L., von Dassow P., Wilhelm S.W., Collier J.L. 2018. Strength in numbers: Collaborative science for new experimental model systems. PLoS Biology. 16(7): e2006333 doi: 10.1371/journal.pbio.2006333
Rafels-Ybern, A.; Torres, A.G.; Grau-Bove, X.; Ruiz-Trillo, I.; Ribas de Pouplana, L. 2018. Codon adaptation to tRNAs with Inosine modification at position 34 is widespread among Eukaryotes and present in two Bacterial phyla. RNA Biology, DOI: 10.1080/15476286.2017.1358348