Throughout the Earth’s history, evolution has developed a great number of different organisms with an incredible variety of forms and sizes. These morphologies are tailored during development by modifying the expression pattern of key genes and by the modulation of hormone activation. The main goal of this lab is, therefore, to understand how changes in gene and hormone regulation affect morphology evolution, particularly in relation to the origin of insect metamorphosis. The Evolution and Developmental Biology lab addresses these questions by comparing the development and metamorphosis of Drosophila melanogaster, Tribolium castaneum and Thermobia domestica.
Ureña, E.; Pirone, L.; Chafino, S.; [5 authors]; Blanco, F. J.; Barrio, R.; Martín, D. 2016. Evolution of SUMO function and chain formation in insects. Molecular Biology and Evolution 33(2):568-84
Mansilla, A.; Martín, F.A.; Martín, D.; and Ferrús, A. 2016. Ligand-independent requirements of steroid receptors EcR and USP for cell survival. Cell Death & Differentiation 23: 405-416.
Herboso, L.; Oliveira, M. M.; Talamillo, A.; Pérez, C.; González, M.; Martín, D.; Sutherland, J. D.; Shingleton, A. W.; Mirth, C. K.; Barrio, R. 2015. Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster. Scientific Reports 5: 12383.