Throughout the Earth’s history, evolution has developed a great number of different organisms with an incredible variety of forms and sizes. These morphologies are tailored during development by modifying the expression pattern of key genes and by the modulation of hormone activation. The main goal of this lab is, therefore, to understand how changes in gene and hormone regulation affect morphology evolution, particularly in relation to the origin of insect metamorphosis. The Evolution and Developmental Biology lab addresses these questions by comparing the development and metamorphosis of Drosophila melanogasterTribolium castaneum and Thermobia domestica.

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Borras-Castells, F.; Nieva, C.; Maestro, J.L.; Maestro, O.; Belles, X.; Martín, D. 2017. Juvenile hormone biosynthesis in adult Blattella germanica requires nuclear receptors Seven-up and FTZ-F1. Sci Rep 7:40234.

Ureña; E.; Chafino, S.; Manjón, C.; Franch-Marro, X.; and Martín, D. 2016. The Occurrence of the Holometabolous Pupal Stage Requires the Interaction between E93, Krüppel-Homolog 1 and Broad-ComplexPLoS Genetics 12(5):e1006020

Ureña, E.; Pirone, L.; Chafino, S.; [5 authors]; Blanco, F. J.; Barrio, R.; Martín, D. 2016. Evolution of SUMO function and chain formation in insects. Molecular Biology and Evolution 33(2):568-84

Mansilla, A.; Martín, F.A.; Martín, D.; and Ferrús, A. 2016. Ligand-independent requirements of steroid receptors EcR and USP for cell survival. Cell Death & Differentiation 23: 405-416.

de Miguel, C.; Linsler, F.; Casanova, J.; Franch-Marro, X. 2016. Genetic basis for the evolution of organ morphogenesis. The case of spalt and cut in development of insect tracheaDevelopment pii: dev.134924

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