Throughout the Earth’s history, evolution has developed a great number of different organisms with an incredible variety of forms and sizes. These morphologies are tailored during development by modifying the expression pattern of key genes and by the modulation of hormone activation. The main goal of this lab is, therefore, to understand how changes in gene and hormone regulation affect morphology evolution, particularly in relation to the origin of insect metamorphosis. The Evolution and Developmental Biology lab addresses these questions by comparing the development and metamorphosis of Drosophila melanogasterTribolium castaneum and Thermobia domestica.

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Ureña,E.; Manjón, C.; Franch-Marro, X.; and Martín, D. 2014. Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects. Proceedings of the National Academy of Sciences 111 (19):7024-7029


Djabrayan, N.J.V.; Cruz, J.; de Miguel, C.; Franch-Marro, X., and Casanova, J. 2014. Specification of Differentiated Adult Progenitors via Inhibition of Endocycle Entry in the Drosophila Trachea. Cell Reports 9(3): 859-865.


Wendler, F.;  Bota-Rabassedas, N.; Franch-Marro, X. 2013. Cancer becomes wasteful: emerging roles of exosomes in cell-fate determinationJournal of Extracellular Vesicles.


Boulan, L.;  Martín, D.; Milán, M. 2013. bantam miRNA Promotes Systemic Growth by Connecting Insulin Signaling and Ecdysone Production. Current Biology. 23 (6):473-478


Mané-Padrós, D.; Borr.s-Castells, F.; Bellés, X.; Martín, D.  2012. Nuclear receptor HR4 plays an essential role in the ecdysteroid-triggered gene cascade in the development of the hemimetabolous insect Blattella germanica. Molecular and Cellular Endocrinology 348: 322-330.

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