The key question in genomics is how genomes vary and evolve at both large and fine scales. The Evolutionary and Functional Genomics lab is particularly interested in understanding the molecular processes underlying adaptive evolution and the functional consequences of adaptive mutations. Towards this end, -omics strategies with detailed molecular and functional analyses of the candidate adaptive mutations are combined in order to arrive at a comprehensive picture of adaptation. This lab studies both transposable element (TE)-induced adaptations and point mutations in the model organism Drosophila melanogaster. It is also interested in the population dynamics of TEs. TEs are the most active, diverse, and ancient components in a broad range of genomes. As such, a complete understanding of genome function and evolution cannot be achieved without a thorough understanding of TE impact and TE biology.

Lab website: González Lab

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Publications Publications

Salces-Ortiz J.; Vargas-Chavez C.; Guio L.; Rech G.E.; González J. 2020. Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster.. The Royal Society. 375(1795) doi: 10.1098/rstb.2019.0341

Kapun M.; Barron M.; Staubach F.; ...[ 39 authors ]...Betancourt A.; Flatt T.; González J. 2020. Genomic analysis of European Drosophila melanogaster populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses. molecular biology and evolution.

Villanueva-Cañas J.L.; Horvath Aguilera;L. V; González, J 2019. Diverse families of transposable elements affect the transcriptional regulation of stress-response genes in Drosophila melanogaster. Nucleic Acids Research. doi:10.1093/nar/gkz490

Rech G.E.; Bogaerts-Márquez M.; Barrón M.G.; Merenciano M.; Villanueva-Cañas J.L.; Horváth V.; Fiston-Lavier A.-S.; Luyten I.; Venkataram S.; Quesneville H.; Petrov D.A.; González J. 2019. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. PLoS Genetics. 15 (2): e1007900 doi: 10.1371/journal.pgen.1007900

Merenciano M.; Iacometti C.; González J. 2019. A unique cluster of roo insertions in the promoter region of a stress response gene in Drosophila melanogaster. Mobile DNA. 10 (1):10 doi: 10.1186/s13100-019-0152-9