This lab carries out research into different aspects of human genetic diversity, such as the architecture of the genetic predisposition to complex disease and of human adaptation. To this end, sequencing data from different control/case settings or geographically diverse populations are often analysed, and methods for rare variant association and genome-wide detection of selection are subsequently applied. By using in silico predictions, molecular biology techniques and phenotypic data, the Evolutionary Population Genetics lab aims to elucidate the genetic variants and molecular phenotypes underlying the functional basis of different human adaptations.

Lab website: Bosch Lab

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Font-Porterias N, Caro-Consuegra R, Lucas-Sánchez M, Lopez M, Giménez A, Carballo A, Bosch E, Calafell F, Quintana-Murci L, Comas D. 2021. The counteracting effects of demography on functional genomic variation: the Roma paradigm. Molecular Biology and Evolution. DOI: 10.1093/molbev/msab070. 

Walsh S.; Izquierdo-Serra M.; Acosta S.; Edo A.; Lloret M.; Moret R.; Bosch E.; Oliva B.; Bertranpetit J. and  Fernández-Fernández J.M. 2020. Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population. Scientific Reports. 10(1):20999. doi: 10.1038/s41598-020-78081-z.

Muntané G.; Farré X.; Bosch E.; Martorell L.; Navarro A. and Vilella E. 2020. The shared genetic architecture of schizophrenia, bipolar disorder and lifespan. uman Genetics.  doi: 10.1007/s00439-020-02213-8

Gil E.; Fedetz M.; Eixarch H.;...[ 12 authors ]...; Bosch E.; Navarro A.; Alcina A.; Montalban X.; Matesanz F. and Comabella M 2020. A New Risk Variant for Multiple Sclerosis at 11q23.3 Locus Is Associated with Expansion of CXCR5+ Circulating Regulatory T Cells.. Journal of clinical Medicine. 9(3)  doi: 10.3390/jcm9030625.

Gil-Varea E; Spataro N; Villar L.M.; Tejeda-Velarde A.; Midaglia L.; Matesanz F.; Malhotra S.; Eixarch H.; Patsopoulos N.; Fernández Ó.; Oliver-Martos B.; Saiz A. Llufriu S.; Ramió-Torrentà L.; Quintana E.; Izquierdo G.; Alcina A.; Bosch E.; Navarro A.; Montalban X.; Comabella M. 2020. Targeted resequencing reveals rare variants enrichment in multiple sclerosis susceptibility genes.. Human Mutation. doi: 10.1002/humu.24016