This lab carries out research into different aspects of human genetic diversity, such as the architecture of the genetic predisposition to complex disease and of human adaptation. To this end, sequencing data from different control/case settings or geographically diverse populations are often analysed, and methods for rare variant association and genome-wide detection of selection are subsequently applied. By using in silico predictions, molecular biology techniques and phenotypic data, the Evolutionary Population Genetics lab aims to elucidate the genetic variants and molecular phenotypes underlying the functional basis of different human adaptations.

Lab website: Bosch Lab

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Santpere, G.; Carnero-Montoro., E.; Petit, N.; [5 authors]; Dopazo, H.; Navarro, A.; Bosch, E. 2015. Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements. Genome Biology and Evolution 7(6): 1490-1505.


Engelken, J.; Carnero-Montoro, E.; Pybus, M.; Andrews, G.K.; Lalueza-Fox, C.; Comas, D.; Sekler, I.; de la Rasilla, M.; Rosas, A.; Stoneking, M.; Valverde, M.A.; Vicente, R.; and Bosch, E. 2014. Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa. PLoS Genet. 10 (2):e1004128


Cenit, M.C.; Martínez-Florensa, M.; Consuegra, M.; [13 authors]; Bosch, E.; Martín, J.; and Lozano, F. 2014. Analysis of Ancestral and Functionally Relevant CD5 Variants in Systemic Lupus Erythematosus Patients. Plos One 9(11): e113090.


Sturm, S.;  Engelken, J.; Gruber, A.; Vugrinec, S.; G Kroth, P.; Adamska, I.; Lavaud, J. 2013. A novel type of light-harvesting antenna protein of red algal origin in algae with secondary plastids. BMC Evolutionary Biology. 13 (1):159


Spataro, N.;  Farfan, M.; Albarral, V.;  Sanglas, A.;  Lorén, J.G.;  Fusté, MC.;  Bosch, E. 2013. Draft GenomeSequence of Aeromonos molluscorum Strain 848T, Isolated from Bivalve MollucsGenome Announcements. 1 (3):e00382


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