This lab carries out research into different aspects of human genetic diversity, such as the architecture of the genetic predisposition to complex disease and of human adaptation. To this end, sequencing data from different control/case settings or geographically diverse populations are often analysed, and methods for rare variant association and genome-wide detection of selection are subsequently applied. By using in silico predictions, molecular biology techniques and phenotypic data, the Evolutionary Population Genetics lab aims to elucidate the genetic variants and molecular phenotypes underlying the functional basis of different human adaptations.

Lab website: Bosch Lab

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Spataro, N.; Roca-Umbert, A.; Cervera-Carles, L.; Vallès, M.; Anglada, R.; Pagonabarraga, J.; Pascual-Sedano, B.; Campolongo, A.; Kulisevsky, J.; Casals, F.; Clarimón, J.; and Bosch, E. 2016. Detection of genomic rearrangements from targeted resequencing data in Parkinson's disease patients. Mov Disord 32 (1), 165-169

Engelken, J.; Espadas, G.; Mancuso, F.M.; Bonet, N.; Scherr, A.L.; Jímenez-Álvarez, V.; Codina-Solà, M.; Medina-Stacey, D.; Spataro, N.; Stoneking, M.; Calafell, F.; Sabidó, E.; and Bosch, E. (2016). Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in LiverMolecular Biology and Evolution

Spataro, N.; Calafell, F.; Cervera-Carles, L.; [6 authors]; Navarro, A.; iClarimón, J.; Bosch, E. 2015. Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease. Human Molecular Genetics 24(7): 2023-2034.


Santpere, G.; Carnero-Montoro., E.; Petit, N.; [5 authors]; Dopazo, H.; Navarro, A.; Bosch, E. 2015. Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling between the Action of Selection on Protein-Coding and on Noncoding Elements. Genome Biology and Evolution 7(6): 1490-1505.


Engelken, J.; Carnero-Montoro, E.; Pybus, M.; Andrews, G.K.; Lalueza-Fox, C.; Comas, D.; Sekler, I.; de la Rasilla, M.; Rosas, A.; Stoneking, M.; Valverde, M.A.; Vicente, R.; and Bosch, E. 2014. Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa. PLoS Genet. 10 (2):e1004128


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