This lab carries out research into different aspects of human genetic diversity, such as the architecture of the genetic predisposition to complex disease and of human adaptation. To this end, sequencing data from different control/case settings or geographically diverse populations are often analysed, and methods for rare variant association and genome-wide detection of selection are subsequently applied. By using in silico predictions, molecular biology techniques and phenotypic data, the Evolutionary Population Genetics lab aims to elucidate the genetic variants and molecular phenotypes underlying the functional basis of different human adaptations.

Lab website: Bosch Lab

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Farfán, M.;  Spataro, Ni.; Sanglas, A.; Albarral, V.; Lorén, J. G.; Bosch, E.; Fusté, M. Carmen. 2013. Draft Genome Sequence of the Aeromonas diversa Type Strain. Genome Announcements. 1 (3)


Carnero-Montoro, E.; Bonet, L.; Engelken, J.; Bielig, T.; Martínez-Florensa, M.; Lozano, F.; Bosch, E.  2012. Evolutionary and functional evidence for positive selection at the human CD5 immune receptor gene. Molecular Biology and Evolution 29 (2): 811-823.

Myles, S.; Lea, R. A.; Ohashi, J.; [3 authors]; Engelken, J.; [4 authors]; Inaoka, T.; Matsumura, Y.; Stoneking, M. 2011. Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans. BMC Medical Genetics 12: 10.

Laayouni H.; Montanucci L.; Sikora M.; [6 authors]; Bosch E.; Comas D.; Navarro A.; Calafell F.; Casals F.; Bertranpetit J. 2011. Similarity in recombination rate estimates highly correlates with genetic differentiation in humansPLoS ONE 6(3): e17913. doi:10.1371/journal.pone.0017913.

Gazave E, D. F.; Morcillo-Suarez C.; Petit-Marty N.; [5 authors]; Bosch E.; Baker C.; Marquès-Bonet T.; Eichler EE.; Navarro A. 2011. Copy number variation analysis in the great apes reveals species-specific patterns of structural variationGenome Research 21: 1626-1639.

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