The goal of this lab is to understand the origin of animal multicellularity from a unicellular ancestor. To this end, the genomes of animals’ closest unicellular relatives are obtained in order to perform comparative and functional genomics. Moreover, the Multicellgenome lab is working on the development of genetic tools in two close unicellular relatives of animals with the purpose of establishing them as model organisms for addressing the origin of Metazoa. This will enable the elucidation of the ancestral function of the genes involved in multicellularity and offer insight into how they were co-opted.

Lab website: Multicellgenome Lab

Investigador principal Investigador principal

Membres del grup Membres del grup

Projectes en curs Projectes en curs

Publicacions Publicacions

López-Escardó D.; Paps J.; De Vargas C.; Massana R.; Ruiz-Trillo I.; Del Campo J. 2018. Metabarcoding analysis on European coastal samples reveals new molecular metazoan diversity. Scientific Reports. 8(1):9106 doi: 10.1038/s41598-018-27509-8


Schultheiss, K.P.; Suga, H.; Ruiz-Trillo, I.; Miller, W.T.  2012. Lack of Csk-mediated negative regulation in a unicellular Src kinase. Biochemistry 51 (41): 8267-8277. 

Sebé-Pedrós, A.; Zheng, Y.; Ruiz-Trillo, I.; Duojia, P.  2012. Premetazoan origin of the Hippo signaling pathway. Cell Reports 1 (1): 13-20. doi: 10.1016/j.cel-rep.2011.11.004.

Shadwick, J.D.L. and Ruiz-Trillo, I.  2012. A genomic survey shows that the haloarchaeal type Tyrosyl-Synthetase is not a Synapomorphy of Opisthokonts. European Journal of Protistology 48 (1): 89-93.

Suga, H.; Dacre, M.; de Mendoza, A.; Shalchian-Tabrizi, K.; Manning, G.; Ruiz-Trillo, I.  2012. Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases. Science Signaling 5 (222), ra35. doi: 10.1126/scisignal.2002733.