Principal Investigator: Francesc Calafell Principal Investigator: Francesc Calafell

 

Research lines Research lines

The general topics that interest us revolve around the genomics in the study levels that go from the individual to the population. We want to address questions about the individuals, their identities, their phenotypes, and their genomes. Or about groups of individuals connected by shallow or deep genealogical links marked by their surnames or their Y chromosomes. Or about populations, their history, and their interaction as revealed by the bits and pieces of their genomes they have exchanged, never forgetting that these exchanges involved actual people, communicating with their languages and moving with the flow of history.

This vision is currently implemented  in two main projects:

  • Different male lineages marked by Y-chromosome haplogroups have rapidly grown in many places and in many (pre)historic times. We are interested in characterizing phylogeoghraphically two such haplogroups: R1b-DF27, carried by >40% of men in the Iberian Peninsula and rarer elsewhere, and E-M81, again much more frequent in NW Africa than elsewhere. We plan also to explore which demographic regimes could have led these local expansions. This project is carried out in collaboration with Marian Martínez de Pancorbo (Universidad del País Vasco) and David Comas here at IBE (CSIC-UPF).
  • We are interested in characterizing the genetic structure, at a fine geographical and genomic scale, of the Western Mediterranean, defined as Iberia, France, the Italian Peninsula, the Maghreb, and the islands in the W Mediterranean basin. For that, we use genomewide SNP arrays in >400 samples we have gathered from several regions in Iberia and France, as well as in the Balearic Islands, which will be merged with SNP sets from Italian regions (provided by Giuseppe Matullo, Turin) and NW Africa (David Comas, IBE). The main goals of these project are i) to characterize the genetic structure of the area, ii) estimate gene flow within populations in the area and from external sources such as the Middle East and the East European steppe by means of the current methods that allow tracking the exchange of haplotypes between individuals and populations, and iii) in particular,  investigate the Balearic islands, which may be prone to founder effects and subsequent drift.

 

Lab website: Calafell Lab

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Principal Investigator Principal Investigator

Current members Current members

Publications since 2011 Publications since 2011

Villaescusa, P.; Illescas, M.J.; Valverde, L.; Baeta, M.; Nuñez, C.; Martínez-Jarreta, B.; Zarrabetia, M.T.; Calafell, F.; de Pancorbo, M.M. 2017. Characterization of the Iberian Y chromosome haplogroup R-DF27 in Northern Spain. Forensic science international. 27: 142-148


Perez de los Cobos, J.M.D.; Alcaraz, S.; Siñol, N.; Arranz, M.J.; Trujols, J.; Battle, F.; Calafell, F.; Durán-Sindreu, S.;Salazar,J. 2017. Satisfaction With Methadone and Opioid Receptor Genes Polymorphisms in Treatment-Refractory Heroin-Dependent Patients. Journal of Clinical psychopharmacology. 37(3): 378-380


Moreno,F.;Indakoetxea, B.;Barandiaran, M.; Caballero, M.C.; Gorostidi, A.; Calafell, F.; Gabilondo, A.; Tainta, M.; Zulaica, M.; Martí Massó, J.F.; López de Munain, A.; Sánchez-Juan, P.; Lee, S.E. 2017. The unexpected co-occurrence of GRN and MAPT p.A152T in Basque families: Clinical and pathological characteristics Plos One. 8;12(6): e0178093


Mondal, M.; Bergström, A.; Xue, Y.; Calafell, F.; Laayouni, H.; Casals, F.; Majumder, P.P.; Tyler-Smith, C.; Bertranpetit, J. 2017. Y-chromosomal sequences of diverse Indian populations and the ancestry of the Andamanese. Hum Genet. Epub ahead of print]

Casals, F.; Anglada, R.; Bonet, N.; Rasal, R.; Van der Gaag, K. J.; Hoogenboom, J.; Solé-Morata, N.; Comas, D.; Calafell, F. 2017. Length and repeat-sequence variation in 58 STRs and 94 SNPs in two Spanish populations Forensic Science International: Genetics. 30: 66-70


Ongoing projects Ongoing projects

In the media In the media

On the publication of Jaume Bertranpetit and Francesc Calafell's new project:


3rd January, 2017. Cadena SER (Radio Zaragoza). "Conocer tus orígenes geográficos a través del ADN" (with the participation of Francesc Calafell).


23rd June, 2016. Quo. "Nadar no es humano" (with the participation of Frances Calafell).


On the publication of the article "Y-chromosome diversity in Catalan surname samples: insights into surname origin and frequency", with the participation of Jaume Bertranpetit, David Comas and Francesc Calafell


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