As its name reveals, the interests of this lab’s research are focused on the analysis of the human genome diversity with the aim of inferring the genomic and population processes that are responsible for this diversity, and outlining the population and epidemiological consequences of the human genetic variability. Its main research lines are, therefore, not only connected with human genome diversity, but also with population genetics, genome variation and disease susceptibility, and genome evolution and disease.

Lab website: Comas Lab

Principal Investigator Principal Investigator

Current members Current members

Ongoing projects Ongoing projects

Publications Publications

Secolin R.; Mas-Sandoval A.;  Arauna L.; Torres F.R.; de Araujo T.K.;  Santos M.L.; Rocha C.S.;  Carvalho B.S.; Cendes F.;  Lopes-Cendes I. & Comas D. 2019. Distribution of local ancestry and evidence of adaptation in admixed populations. Scientific Reports. doi.org/10.1038/s41598-019-50362-2
 


Rabionet R.; Remesal A.; Mensa-Vilaró A.; Murías S.; Alcobendas R.; González-Roca E.; Ruiz-Ortiz E.; Antón J.; Iglesias E.; Modesto C.; Comas D.; Puig A.; Drechsel O.; Ossowski S.; Yagüe J.; Merino R.; Estivill X.; Arostegui J.I. 2019. Biallelic loss-of-function LACC1/FAMIN Mutations Presenting as Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis. Scientific Reports. 9(1):4579 doi: 10.1038/s41598-019-40874-2

Arauna L.; Hellentha G. and David Comas. 2019. Dissecting human North African gene-flow into its western coastal surroundings. The royal society. () doi: doi.org/10.1098/rspb.2019.0471
 


Alex Mas-Sandoval A.; Arauna L.R.; Gouveia M.H.; Barreto M.L.; Horta B.L.; Lima-Costa M.F.; Pereira A.C.;  Salzano F.M.; Hunemeier T.; Tarazona-Santos E.; Bortolini M.C.and Comas D. 2019. Reconstructed Lost Native American Populations from Eastern Brazil Are Shaped by Differential Je/Tupi Ancestry. Genome Biol. Evol. 2593–2604.doi:10.1093/gbe/evz161
 


Viscardi L.H., Paixão-Côrtes V.R., Comas D., Salzano F.M., Rovaris D., Bau C.D., Amorim C.E.G., Bortolini M.C. 2018. Searching for ancient balanced polymorphisms shared between Neanderthals and modern humans. Genetics and Molecular Biology. 41(1):67-81 doi: 10.1590/1678-4685-gmb-2017-0308