Algorithms for Population Genomics
Our Group focuses on human species but the universality of the proposed methods allows us to apply them to other model organisms.
Serradell JM, Lorenzo-Salazar JM, Flores C, Lao O, Comas D. 2024. Modelling the demographic history of human North African genomes points to a recent soft split divergence between populations. Genome Biology, 25(1):201. DOI:10.1186/s13059-024-03341-4
Roca-Ayats N, Maceda I, Bruque CD, Martínez-Gil N, Garcia-Giralt N, Cozar M, Mellibovsky L, Van Hul W, Lao O, Grinberg D, Balcells S. 2024. Evolutionary and functional analyses of LRP5 in archaic and extant modern humans. Human Genomics, 18(1):53. DOI:10.1186/s40246-024-00616-6
Huang X, Rymbekova A, Dolgova O, Lao O, Kuhlwilm M. 2023. Harnessing deep learning for population genetic inference. Nature Reviews Genetics. DOI:10.1038/s41576-023-00636-3
Moreno-Ruiz N; Genomics England Research Consortium, Lao O, Aróstegui JI, Laayouni H, Casals F. 2022. Assessing the digenic model in rare disorders using population sequencing data. European Journal of Human Genetics, 30(12):1439-1443. DOI:10.1038/s41431-022-01191-x.