Principal Investigator: Tomàs Marquès-Bonet Principal Investigator: Tomàs Marquès-Bonet

 

Research lines Research lines

Our main line of research is centered on the discovery of the extent of all kinds of genome variation within phenotypically different genomes. Specifically, we study genome variation (centered on CNVs), gene expression and epigenetic differences in the human species in the context of great ape evolution and other mammalian genomes such as canids. Our goal is to create an integrated view of genome evolution by studying changes in the composition, frequency, size and location at every major branch point of recent human evolution.

Genomic variation in ape genomes

Characterizing the variation of thousands of human genomes is standard today. However, primates (our closest relatives) are the ideal set of species for studying the evolution of these features from both mechanistic and adaptive points of view. In this line of research, we use genomic approaches in humans and primates to understand the impact of variants in the evolution of every species to provide a proper perspective to the differences among species.

Epigenetics and transcriptomics of non-human primates

DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex disease. However, the dynamics of DNA methylation changes between humans and their closest relatives is still poorly understood. In this project, we evaluate methylation patterns in recent human evolution. We identified a significant positive relationship between the rate of coding variation and alterations of methylation at the promoter level.

Canid evolution

The domestic dog has been widely recognized as an important organism for studying the relationship between selection, genome variation and phenotypic diversity. Both dogs and wolves have been extensively surveyed using mtDNA, microsatellites and SNPs,  but structural variation, including variation in multicopy gene families, has not been fully characterized in canines.

 

Lab website: Comparative Genomics Lab

News News

Principal Investigator Principal Investigator

Current members Current members

Publications since 2011 Publications since 2011

Nam, K.; Munch, K.; Mailund, T.; Nater, A.; Greminger, M.P.; Krützen, M.; Marquès-Bonet, T.; Schierup, M.H. 2017. Evidence that the rate of strong selective sweeps increases with population size in the great apes. Proc Natl Acad Sci U S A. pii: 201605660. doi: 10.1073/pnas.1605660114. [Epub ahead of print]


McConnell, M.J.; Moran, J.V.; Abyzov, A.; Akbarian, S.; Bae, T.; Cortes-Ciriano, I.; Erwin, J.A.; Fasching, L.; Flasch, D.A.; Freed, D.; Ganz, J., Jaffe, A.E.; Kwan, K.Y.; Kwon, M.; Lodato, M.A.; Mills, R.E.; Paquola, A.C.M.; Rodin, R.E.; Rosenbluh, C.; Sestan, N.; Sherman, M.A.; Shin, J.H.; Song, S.; Straub, R.E.; Thorpe, J.; Weinberger, D.R.; Urban, A.E.; Zhou, B.; Gage, F.H.; Lehner, T.; Senthil, G.; Walsh, C.A.; Chess, A.; Courchesne, E.; Gleeson, J.G.; Kidd, J.M.;  Park, P.J.; Pevsner, J.; Vaccarino, F.M.; Brain Somatic Mosaicism Network. 2017. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science  356:6336 eaal1641

Librado, P.; Gamba, C.; Gaunitz, C.; Der Sarkissian, C.; Pruvost, M.; Albrechtsen, M.; Fages, A.; Khan, N.; Schubert, M.; Jagannathan, V.; Serres-Armero, A.; Kuderna, L.F.K; Povolotskaya, I.S.; Seguin-Orlando, A.; Lepetz, S.; Neuditschko, M.; Thèves, C.; Alquraishi, S.; Alfarhan, A.H.; Al-Rasheid, K.; Rieder, S.; Samashev, Z.; Francfort, H.-P.; Benecke, N.; Hofreiter, M.; Ludwig, A.; Keyser, C.; Marques-Bonet, T.; Ludes, B.; Crubézy, E.; Leeb, T.; Willerslev, E.; Orlando, L. 2017. Ancient genomic changes associated with domestication of the horse. Science, 356 (6336):442-445.

Stevison, L.S.; Woerner, A.E.; Kidd, J.M.; Kelley, J.L.; Veeramah, K.R.; McManus, K.F.; Great Ape Genome Project; Bustamante, C.D.; Hammer, M.F.; Wall, J.D. 2016. The Time Scale of Recombination Rate Evolution in Great Apes. Mol Biol Evo 33(4):928-45

Sanchez-Delgado, M.; Court, F.; Vidal, E.; Medrano, J.; Monteagudo-Sánchez, A.; Martin-Trujillo, A.; Tayama, C.; Iglesias-Platas, I.; Kondova, I.; Bontrop, R.; Poo-Llanillo, M.E.; Marques-Bonet, T.; Nakabayashi, K.; Simón, C.; and Monk, D. 2016. Human Oocyte-Derived Methylation Differences Persist in the Placenta Revealing Widespread Transient Imprinting. PLoS Genet 12(11):e1006427

Ongoing projects Ongoing projects

In the media In the media

3rd August, 2017. Diari Ara“És urgent tenir un debat sobre l’edició d’embrions”. With comments of Tomàs Marquès-Bonet.

 


On the publication of the article "Continuity and Admixture in the Last Five Millennia of Levantine History from Ancient Canaanite and Present-Day Lebanese Genome Sequences", with the participation of Javier Prado Martínez, former member of Tomàs Marquès-Bonet's group:


24th July, 2017. El Mundo (Comunidad Valenciana Edition). "Las valencianas Clara Murgui y Lucía Zhu, entre las 48 becadas para el doctorado 'la Caixa' Severo Ochoa". On the "la Caixa" scholarships. Mentions Luis José Ferrández, Tomàs Marquès' PhD student.

On a Tomàs Marquès-Bonet's article:


16th June, 2017. La Vanguardia. "Las noticias también se contagian" (mentions Tomàs Marquès-Bonet).