Life as we see it in our planet today has been shaped by many different biological processes, particularly natural selection, during billions of years. These processes leave a signature in our genomes in the form of differences between species, or between individuals of the same species. Interrogating these patterns of genome diversity we can infer what are the forces that affect living organisms, how and when they act and how do they affect such various things as biodiversity, human emotions or the differential susceptibility of different persons to certain diseases. All this knowledge empowers us to control our future but, above all, it is very fun to obtain.

Currently, the main research goals of the group focus on to elucidating how evolution, and particularly natural selection, has shaped genome and phenotype diversity in our lineage. To this end, we combine experiments, models and data analysis. Some specific research lines are as follows:

 

Chromosomal evolution and speciation 

We study how large chromosomal rearrangements affect many aspects of genome structure and evolution, including how they may drive the generation of new species.

 

Segmental duplications and copy-number variation in primates 

The genomes of humans and other primates show an enrichment in Segmental Duplications (SDs) with high sequence identity, plus they present may Copy-Number Variants (CNVs), large genome fragments of which different individuals present different copies. SDs and CNVs are fundamental for the creation of novel genes and may have been key in the evolution of our lineage. We study not only the frequencies and genome locations of these variants, but also the molecular evolution of their sequence content.

 

Detecting the genomic signature of natural selection 

We try to detect the signature of adaptive changes out of single-copy protein-coding regions. We focus in how natural selection may have shaped variability patterns in introns and regulatory regions of genes.

 

Human disease and its evolutionary implications 

We study world-wide patterns of disease susceptibility distribution to ascertain how these may have been influenced by recent human evolution. In addition, we investigate the possible origins of Multiple Sclerosis and its possible relationship with very recent natural selection events in humans.

 

Genoeconomics 

Complex human traits that are exclusive of our lineage are the basis of our societies and have huge socio-economic impact. We deploy the latest tools of genomics for the dissection of human economic traits.

 

Lab website: Evolutionary Genomics Lab

Arcadi Navarro Cuartiellas

Navarro Cuartiellas, Arcadi
ICREA Research Professor
Evolutionary Genomics Lab

Fabio Barteri

Barteri, Fabio
Personal de suport a la recerca
Evolutionary Genomics

Gerard Muntané Medina

Muntané Medina, Gerard
Visiting- Associate professor
Evolutionary Genomics Lab

Gouy A, Daub JT, Excoffier L. 2017. Detecting gene subnetworks under selection in biological pathways. Nucleic Acids Research, 45(16):e149-e149. DOI:10.1093/nar/gkx626

Gaubert P, Patel RP, Veron G, Goodman SM, Willsch M, Vasconcelos R, Lourenço A, Sigaud M, Justy F, Joshi BD, Fickel J, Wilting A. 2017. Phylogeography of the small indian civet and origin of introductions to western indian ocean islands. Journal of Heredity, 108(3):270-279. DOI:10.1093/jhered/esw085

Fernández C, Bellosillo B, Ferraro M, Seoane A, Sánchez-González B, Pairet S, Pons A, Barranco L, Vela MC, Gimeno E, Colomo L, Besses C, Navarro A, Salar A. 2017. MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT lymphomas compared to chronic gastritis. Cancer Genomics and Proteomics, 14(1):75-82. DOI:10.21873/cgp.20020

Alanis-Lobato G, Andrade-Navarro MA, Schaefer MH. 2017. HIPPIE v2.0: Enhancing meaningfulness and reliability of protein-protein interaction networks. Nucleic Acids Research, 45(D1):D408-D414. DOI:10.1093/nar/gkw985

Stange J, Dickhaus T, Navarro A, Schunk D. 2016. Multiplicity- and dependency-adjusted p-values for control of the family-wise error rate. Statistics and Probability Letters, 111:32-40. DOI:10.1016/j.spl.2016.01.005

Santpere G, Lopez-Valenzuela M, Petit-Marty N, Navarro A, Espinosa-Parrilla Y. 2016. Differences in molecular evolutionary rates among microRNAs in the human and chimpanzee genomes. BMC Genomics, 17(1):1-12. DOI:10.1186/s12864-016-2863-3

Pinho C, Faria R. 2016. Magadi tilapia ecological specialization: Filling the early gap in the speciation continuum. Molecular Ecology, 25(7):1420-1422. DOI:10.1111/mec.13598

Mieth B, Kloft M, Rodríguez JA, Sonnenburg S, Vobruba R, Morcillo-Suárez C, Farré X, Marigorta UM, Fehr E, Dickhaus T, Blanchard G, Schunk D, Navarro A, Müller KR. 2016. Combining multiple hypothesis testing with machine learning increases the statistical power of genome-wide association studies. Scientific Reports, 6(November):1-14. DOI:10.1038/srep36671

Lobon I, Tucci S, de Manuel M, Ghirotto S, Benazzo A, Prado-Martinez J, Lorente-Galdos B, Nam K, Dabad M, Hernandez-Rodriguez J, Comas D, Navarro A, Schierup MH, Andres AM, Barbujani G, Hvilsom C, Marques-Bonet T. 2016. Demographic history of the genus Pan inferred from whole mitochondrial genome reconstructions. Genome Biology and Evolution, 8(6):2020-2030. DOI:10.1093/gbe/evw124

Hartasánchez DA, Brasó-Vives M, Fuentes-Díaz J, Vallès-Codina O, Navarro A. 2016. SeDuS: Segmental duplication simulator. Bioinformatics, 32(1):148-150. DOI:10.1093/bioinformatics/btv481

Gallego A, Melé M, Balcells I, García-Ramallo E, Torruella-Loran I, Fernández-Bellon H, Abelló T, Kondova I, Bontrop R, Hvilsom C, Navarro A, Marquès-Bonet T, Espinosa-Parrilla Y. 2016. Functional Implications of Human-Specific Changes in Great Ape microRNAs. PLoS ONE, 11(4):1-20. DOI:10.1371/journal.pone.0154194

Dopazo J, Amadoz A, Bleda M, Garcia-Alonso L, Alemán A, García-García F, Rodriguez JA, Daub JT, Muntané G, Rueda A, Vela-Boza A, López-Domingo FJ, Florido JP, Arce P, Ruiz-Ferrer M, Méndez-Vidal C, Arnold TE, Spleiss O, Alvarez-Tejado M, Navarro A, Bhattacharya SS, Borrego S, Santoyo-López J, Antiñolo G. 2016. 267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation. Molecular Biology and Evolution, 33(5):1205-1218. DOI:10.1093/molbev/msw005

de Manuel M, Kuhlwilm M, Frandsen P, Sousa VC, Desai T, Prado-Martinez J, Hernandez-Rodriguez J, Dupanloup I, Lao O, Hallast P, Schmidt JM, Heredia-Genestar JM, Benazzo A, Barbujani G, Peter BM, Kuderna LF, Casals F, Angedakin S, Arandjelovic M, Boesch C, Kühl H, Vigilant L, Langergraber K, Novembre J, Gut M, Gut I, Navarro A, Carlsen F, Andrés AM, Siegismund HR, Scally A, Excoffier L, Tyler-Smith C, Castellano S, Xue Y, Hvilsom C, Marques-Bonet T. 2016. Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science, 354(6311):477-481. DOI:10.1126/science.aag2602

Corrales E, Navarro A, Cuenca P, Campos D. 2016. Candidate gene study reveals DRD1 and DRD2 as putative interacting risk factors for youth depression. Psychiatry Research, 244:71-77. DOI:10.1016/j.psychres.2016.07.032

Chavan R, Shinde P, Girkar K, Madage R, Chowdhary A. 2016. Assessment of Anti-Influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extracts. Pharmacognosy Research, 8(2):105. DOI:10.4103/0974-8490.172562

Carvalho J, Sotelo G, Galindo J, Faria R. 2016. Genetic characterization of flat periwinkles (Littorinidae) from the Iberian Peninsula reveals interspecific hybridization and different degrees of differentiation. Biological Journal of the Linnean Society, 118(3):503-519. DOI:10.1111/bij.12762

Cagan A, Theunert C, Laayouni H, Santpere G, Pybus M, Casals F, Prüfer K, Navarro A, Marques-Bonet T, Bertranpetit J, Andrés AM. 2016. Natural selection in the great apes. Molecular Biology and Evolution, 33(12):3268-3283. DOI:10.1093/molbev/msw215

Buzdugan L, Kalisch M, Navarro A, Schunk D, Fehr E, Bühlmann P. 2016. Assessing statistical significance in multivariable genome wide association analysis. Bioinformatics, 32(13):1990-2000. DOI:10.1093/bioinformatics/btw128

Santpere G, Carnero-Montoro E, Petit N, Serra F, Hvilsom C, Rambla J, Heredia-Genestar JM, Halligan DL, Dopazo H, Navarro A, Bosch E. 2015. Analysis of five gene sets in chimpanzees suggests decoupling between the action of selection on protein-coding and on noncoding elements. Genome Biology and Evolution, 7(6):1490-1505. DOI:10.1093/gbe/evv082

Montes A, Roca G, Sabate S, Lao JI, Navarro A, Cantillo J, Canet J; GENDOLCAT Study Group. 2015. Genetic and Clinical Factors Associated with Chronic Postsurgical Pain after Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study. Anesthesiology, 122(5):1123-1141. DOI:10.1097/ALN.0000000000000611

Lappalainen I, Almeida-King J, Kumanduri V, Senf A, Spalding JD, Ur-Rehman S, Saunders G, Kandasamy J, Caccamo M, Leinonen R, Vaughan B, Laurent T, Rowland F, Marin-Garcia P, Barker J, Jokinen P, Torres AC, de Argila JR, Llobet OM, Medina I, Puy MS, Alberich M, de la Torre S, Navarro A, Paschall J, Flicek P. 2015. The European Genome-phenome Archive of human data consented for biomedical research. Nature Genetics, 47(7):692-695. DOI:10.1038/ng.3312

Hughes DA, Kircher M, He Z, Guo S, Fairbrother GL, Moreno CS, Khaitovich P, Stoneking M. 2015. Evaluating intra- and inter-individual variation in the human placental transcriptome. Genome Biology, 16(1):1-18. DOI:10.1186/s13059-015-0627-z

Bustamante MF, Morcillo-Suárez C, Malhotra S, Rio J, Leyva L, Fernández O, Zettl UK, Killestein J, Brassat D, García-Merino JA, Sánchez AJ, Urcelay E, Alvarez-Lafuente R, Villar LM, Alvarez-Cermeño JC, Farré X, Lechner-Scott J, Vandenbroeck K, Rodríguez-Antigüedad A, Drulovic JS, Martinelli Boneschi F, Chan A, Oksenberg J, Navarro A, Montalban X, Comabella M. 2015. Pharmacogenomic study in patients with multiple sclerosis Responders and nonresponders to IFN-β. Neurology: Neuroimmunology and NeuroInflammation, 2(5):e154. DOI:10.1212/NXI.0000000000000154

Sotelo G, Andree KB, López MA, Alexandrino P, Gisbert E. 2014. The puzzling demographic history and genetic differentiation of the twaite shad (Alosa fallax) in the Ebro River. Conservation Genetics, 15(5):1037-1052. DOI:10.1007/s10592-014-0597-9

Santpere G, Darre F, Blanco S, Alcami A, Villoslada P, Mar Albà M, Navarro A. 2014. Genome-wide analysis of wild-type epstein-barr virus genomes derived from healthy individuals of the 1000 genomes project. Genome Biology and Evolution, 6(4):846-860. DOI:10.1093/gbe/evu054

Rodríguez JA, Marigorta UM, Navarro A. 2014. Integrating genomics into evolutionary medicine. Current Opinion in Genetics and Development, 29:97-102. DOI:10.1016/j.gde.2014.08.009

Pineda S, Milne RL, Calle ML, Rothman N, López de Maturana E, Herranz J, Kogevinas M, Chanock SJ, Tardón A, Márquez M, Guey LT, García-Closas M, Lloreta J, Baum E, González-Neira A, Carrato A, Navarro A, Silverman DT, Real FX, Malats N. 2014. Genetic variation in the TP53 pathway and bladder cancer risk. A comprehensive analysis. PLoS ONE, 9(5):1-8. DOI:10.1371/journal.pone.0089952

Olalde I, Sánchez-Quinto F, Datta D, Marigorta UM, Chiang CW, Rodríguez JA, Fernández-Callejo M, González I, Montfort M, Matas-Lalueza L, Civit S, Luiselli D, Charlier P, Pettener D, Ramírez O, Navarro A, Himmelbauer H, Marquès-Bonet T, Lalueza-Fox C. 2014. Genomic analysis of the blood attributed to Louis XVI (1754-1793), king of France. Scientific Reports, 4:1-7. DOI:10.1038/srep04666

Olalde I, Allentoft ME, Sánchez-Quinto F, Santpere G, Chiang CW, DeGiorgio M, Prado-Martinez J, Rodríguez JA, Rasmussen S, Quilez J, Ramírez O, Marigorta UM, Fernández-Callejo M, Prada ME, Encinas JM, Nielsen R, Netea MG, Novembre J, Sturm RA, Sabeti P, Marquès-Bonet T, Navarro A, Willerslev E, Lalueza-Fox C. 2014. Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European. Nature, 507(7491):225-228. DOI:10.1038/nature12960

Navarro A, Faria R. 2014. Pool and conquer: New tricks for (c)old problems. Molecular Ecology, 23(7):1653-1655. DOI:10.1111/mec.12685

Hartasánchez DA, Vallès-Codina O, Brasó-Vives M, Navarro A. 2014. Interplay of interlocus gene conversion and crossover in segmental duplications under a neutral scenario. G3: Genes, Genomes, Genetics, 4(8):1479-1489. DOI:10.1534/g3.114.012435

Faria R, Renaut S, Galindo J, Pinho C, Melo-Ferreira J, Melo M, Jones F, Salzburger W, Schluter D, Butlin R. 2014. Advances in Ecological Speciation: An integrative approach. Molecular Ecology, 23(3):513-521. DOI:10.1111/mec.12616

Serrano-Munuera C, Corral-Juan M, Stevanin G, San Nicolás H, Roig C, Corral J, Campos B, de Jorge L, Morcillo-Suárez C, Navarro A, Forlani S, Durr A, Kulisevsky J, Brice A, Sánchez I, Volpini V, Matilla-Dueñas A. 2013. New subtype of spinocerebellar ataxia with altered vertical eye movements mapping to chromosome 1p32. JAMA Neurology, 70(6):764-771. DOI:10.1001/jamaneurol.2013.2311

Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prüfer K, Pybus M, Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprubí C, Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S, Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrés AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T. 2013. Great ape genetic diversity and population history. Nature, 499(7459):471-475. DOI:10.1038/nature12228

Prado-Martinez J, Hernando-Herraez I, Lorente-Galdos B, Dabad M, Ramirez O, Baeza-Delgado C, Morcillo-Suarez C, Alkan C, Hormozdiari F, Raineri E, Estellé J, Fernandez-Callejo M, Valles M, Ritscher L, Schöneberg T, de la Calle-Mustienes E, Casillas S, Rubio-Acero R, Melé M, Engelken J, Caceres M, Gomez-Skarmeta JL, Gut M, Bertranpetit J, Gut IG, Abello T, Eichler EE, Mingarro I, Lalueza-Fox C, Navarro A, Marques-Bonet T. 2013. The genome sequencing of an albino Western lowland gorilla reveals inbreeding in the wild. BMC Genomics, 14(1). DOI:10.1186/1471-2164-14-363

Marigorta UM, Navarro A. 2013. High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants. PLoS Genetics, 9(6). DOI:10.1371/journal.pgen.1003566

Malhotra S, Morcillo-Suárez C, Nurtdinov R, Rio J, Sarro E, Moreno M, Castilló J, Navarro A, Montalban X, Comabella M. 2013. Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-β treatment. European Journal of Neurology, 20(10):1390-1397. DOI:10.1111/ene.12193

Lorente-Galdos B, Bleyhl J, Santpere G, Vives L, Ramírez O, Hernandez J, Anglada R, Cooper GM, Navarro A, Eichler EE, Marques-Bonet T. 2013. Accelerated exon evolution within primate segmental duplications. Genome Biology, 14(1):R9. DOI: 10.1186/gb-2013-14-1-r9

Hernando-Herraez I, Prado-Martinez J, Garg P, Fernandez-Callejo M, Heyn H, Hvilsom C, Navarro A, Esteller M, Sharp AJ, Marques-Bonet T. 2013. Dynamics of DNA Methylation in Recent Human and Great Ape Evolution. PLoS Genetics, 9(9). DOI:10.1371/journal.pgen.1003763

Fossion R, Hartasánchez DA, Resendis-Antonio O, Frank A. 2013. Criticality, adaptability and early-warning signals in time series in a discrete quasispecies model. Frontiers in Biology, 8(2):247-259. DOI:10.1007/s11515-013-1256-0

De Maturana EL, Ye Y, Calle ML, Rothman N, Urrea V, Kogevinas M, Petrus S, Chanock SJ, Tardón A, García-Closas M, González-Neira A, Vellalta G, Carrato A, Navarro A, Lorente-Galdós B, Silverman DT, Real FX, Wu X, Malats N. 2013. Application of multi-SNP approaches Bayesian LASSO and AUC-RF to detect main effects of inflammatory-gene variants associated with bladder cancer risk. PLoS ONE, 8(12). DOI:10.1371/journal.pone.0083745

Alcina A, Fedetz M, Fernández O, Saiz A, Izquierdo G, Lucas M, Leyva L, García-León JA, Abad-Grau Mdel M, Alloza I, Antigüedad A, Garcia-Barcina MJ, Vandenbroeck K, Varadé J, de la Hera B, Arroyo R, Comabella M, Montalban X, Petit-Marty N, Navarro A, Otaegui D, Olascoaga J, Blanco Y, Urcelay E, Matesanz F. 2013. Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis. Journal of Medical Genetics, 50(1):25-33. DOI:10.1136/jmedgenet-2012-101085

Petit N, Piñeyro D, López-Panadès E, Casacuberta E, Navarro A. 2012. HeT-A_pi1, a piRNA target sequence in the Drosophila telomeric retrotransposon HeT-A, is extremely conserved across copies and species. PLoS ONE, 7(5):1-11. DOI:10.1371/journal.pone.0037405

Lorente-Galdos B, Medina I, Morcillo-Suarez C, Heredia T, Carreño-Torres A, Sangrós R, Alegre J, Pita G, Vellalta G, Malats N, Pisano DG, Dopazo J, Navarro A. 2012. Select Your SNPs (SYSNPs): a web tool for automatic and massive selection of SNPs. International Journal of Data Mining and Bioinformatics, 6(3):324. DOI:10.1504/IJDMB.2012.049249

Garcia-Mas J, Benjak A, Sanseverino W, Bourgeois M, Mir G, González VM, Hénaff E, Câmara F, Cozzuto L, Lowy E, Alioto T, Capella-Gutiérrez S, Blanca J, Cañizares J, Ziarsolo P, Gonzalez-Ibeas D, Rodríguez-Moreno L, Droege M, Du L, Alvarez-Tejado M, Lorente-Galdos B, Melé M, Yang L, Weng Y, Navarro A, Marques-Bonet T, Aranda MA, Nuez F, Picó B, Gabaldón T, Roma G, Guigó R, Casacuberta JM, Arús P, Puigdomènech P. 2012. The genome of melon (Cucumis melo L.). Proceedings of the National Academy of Sciences of the United States of America, 109(29):11872-11877. DOI:10.1073/pnas.1205415109

Dickhaus T, Straßburger K, Schunk D, Morcillo-Suarez C, Illig T, Navarro A. 2012. How to analyze many contingency tables simultaneously in genetic association studies. Statistical Applications in Genetics and Molecular Biology, 11(4). DOI:10.1515/1544-6115.1776

Cantó E, Reverter F, Morcillo-Suárez C, Matesanz F, Fernández O, Izquierdo G, Vandenbroeck K, Rodríguez-Antigüedad A, Urcelay E, Arroyo R, Otaegui D, Olascoaga J, Saiz A, Navarro A, Sanchez A, Domínguez C, Caminero A, Horga A, Tintoré M, Montalban X, Comabella M. 2012. Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis. Multiple Sclerosis Journal, 18(7):983-990. DOI:10.1177/1352458511433063

Ventura M, Catacchio CR, Alkan C, Marques-Bonet T, Sajjadian S, Graves TA, Hormozdiari F, Navarro A, Malig M, Baker C, Lee C, Turner EH, Chen L, Kidd JM, Archidiacono N, Shendure J, Wilson RK, Eichler EE. 2011. Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. Genome Research, 21(10):1640-1649. DOI:10.1101/gr.124461.111

Vallès-Codina O, Möbius R, Rüdiger S, Schimansky-Geier L. 2011. Traveling echo waves in an array of excitable elements with time-delayed coupling. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 83(3):1-9. DOI:10.1103/PhysRevE.83.036209

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