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Origin, conservation and diversification of IP3R

Origin, conservation and diversification of IP3R

The study provides an evolutionary framework of two of the major Ca2+ channels, IP3 receptors and ryanodine receptors. Ref. Art.: Alzayady KJ, Sebé-Pedrós A, [...], Ruiz-Trillo I, Yule DI (2015). Tracing the Evolutionary History of IP3R: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs. Molecular Biology and Evolution

06.05.2015

 

The study provides an evolutionary framework of two of the major calcium ions (Ca2+) channels, Inositol, 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). Moreover, Ruiz-Trillo group has characterized orthologs of those calcium ion channels in Capsaspora owczarzaki, a close unicellular relative of animals. They show that IP3RA, IP3RB and RyR gene families evolved before the origin of animals. Moreover, they show how one Capsaspora ortholog exhibit basic functionality, while the other is not regulated by common cellular signals known to regulate IP3Rs in different multicellular species. Thus, the researchers suggest that the physiological requirements of multicellular organisms might have necessitated an increase in the IP3R responsiveness to internal and external metabolic signals. The publication is a result of a collaboration with the lab of David I Yule (University of Rochester).

Reference article:
Tracing the Evolutionary History of Inositol, 1, 4, 5-trisphosphate receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs.
Alzayady KJ, Sebé-Pedrós A, Chandrasekhar R, Wang L, Ruiz-Trillo I, Yule DI.
Mol Biol Evol. 2015 Apr 23. pii: msv098. [Epub ahead of print] PMID: 25911230

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