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Epigenetics helps to better understand human evolution from apes

Epigenetics helps to better understand human evolution from apes

Methylated regions are far from the promoters and tend to be enriched for human specific single point mutations. Ref. Art.: Hernando-Herraez I, [7 authors], Marques-Bonet T (2015). The interplay between DNA methylation and sequence divergence in recent human evolution. NAR

01.09.2015

 

In this paper, Tomàs Marquès-Bonet and colleagues look for human specific differential methylated regions comparing Bisulfite data of human to the rest of great apes.

They find that these regions are, surprisingly, far away from the promoters and tend to be enriched for human specific single point mutations, which highlights the impact of genetic background and epigenetic modifications.

 
Reference Article: Hernando-Herraez I, Heyn H, Fernandez-Callejo M, Vidal E, Fernandez-Bellon H, Prado-Martinez J, Sharp AJ, Esteller M, Marques-Bonet T (2015). The interplay between DNA methylation and sequence divergence in recent human evolution. Nucleic Acids Research
 
 

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