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New insight on the role of structural variation in the process of dog domestication and in diversification of phenotypes observed among dog breeds

New insight on the role of structural variation in the process of dog domestication and in diversification of phenotypes observed among dog breeds

Ref article: Ramirez, O., Olalde, I., Berglund,J. Lorente-Galdos, B., Hernandez-Rodriguez, J.,  Quilez, J., Webster,M.T., Wayne, R.,  Lalueza-Fox, C., Vilà, C., Marques-Bonet T.2014. BMC Genomics 15:465  doi:10.1186/1471-2164-15-465

18.06.2014

 

In this work, we make use of previously reported CNVs in modern dog breeds to explore the evolutionary origin of these sites by using a novel panel of wolf-like canids (4 purebred dogs, one dingo, 15 gray wolves, one red wolf, one coyote and one golden jackal). This expanded dataset, combined with our custom-designed higher density array, allowing us to determine the ancestral state and polarize the process of CNV formation in dogs. We identified some candidate genes within CNV regions that are highly differentiated between dogs and wolves,which provide insights into the role of structural variation in the process of dog domestication and in diversification of phenotypes observed among dog breeds

Ref article: Ramirez, O., Olalde, I., Berglund,J.  Lorente-Galdos, B.,  Hernandez-Rodriguez, J.,  Quilez, J., Webster,M.T., Wayne, R.,  Lalueza-Fox, C., Vilà, C.,  Marques-Bonet T.2014. BMC Genomics 15:465  doi:10.1186/1471-2164-15-465

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